Combined effects of alcohol and nicotine on cardiovascular performance in a canine model

Journal of Cardiovascular Pharmacology
M C MehtaM Billie

Abstract

Alcohol and tobacco consumption are correlated. Smokers consume more alcohol than do nonsmokers, and alcohol consumers smoke more than do teetotalers. The independent effects of alcohol and nicotine on the cardiovascular system are well documented, but combined effects of short-term administration are unknown. This experimental work was designed to study the effects due to short-term administration of alcohol and nicotine on cardiovascular system. In phase I, 30 experiments were performed to study the dose-response curve of both the drugs. In phases II and III, 15 dogs were subjected to 30 experiments. In phase II, ethanol, 400 mg/kg, was given i.v., followed by nicotine 50 microg/kg, i.v., and in phase III, sequence of drug administration was reversed to study the effects on hemodynamics and coronary artery blood flow. The dose-response curve established the i.v. dose of ethanol, 400 mg/kg, and nicotine, 50 microg/kg. Ethanol administration caused a nonsignificant increase in heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVS), and left ventricular mechanical work (LVMW), and a decrease in maximal rate of increase of LV pressure per second (dP/dt), stroke volume (SV), and systemic vascular r...Continue Reading

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Citations

Jul 12, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Robert D GaffinBeata M Wolska
May 8, 2003·Biological Procedures Online·Nicholas S. Aberle II, Jun Ren
Aug 21, 2002·The American Journal of the Medical Sciences·Mahaveer C MehtaMike Billie
Apr 13, 2007·Alcoholism, Clinical and Experimental Research·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Dec 25, 2002·Journal of Cardiovascular Pharmacology·Anurag MehtaMahaveer C Mehta
Mar 18, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Mehmet CiftciSenol Dane
Jan 16, 1999·Journal of Cardiovascular Pharmacology·A C JainM Billie
May 18, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Mehmet CiftçiHalis Süleyman
Dec 13, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Kenan GumustekinSenol Dane

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