Combined effects of androgen anabolic steroids and physical activity on the hypothalamic-pituitary-gonadal axis

The Journal of Steroid Biochemistry and Molecular Biology
Jonas HengevossPatrick Diel

Abstract

Analysing effects of pharmaceutical substances and training on feedback mechanisms of the hypothalamic-pituitary-gonadal axis may be helpful to quantify the benefit of strategies preventing loss of muscle mass, and in the fight against doping. In this study we analysed combined effects of anabolic steroids and training on the hypothalamic-pituitary-gonadal axis. Therefore intact male Wistar rats were dose-dependently treated with metandienone, estradienedione and the selective androgen receptor modulator (SARM) S-1. In serum cortisol, testosterone, 17β-estradiol (E2), prolactin, inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), Insulin-like growth factor 1 (IGF-1), and thyroxine (T4) concentrations were determined. Six human volunteers were single treated with 1-androstenedione. In addition abusing and clean body builders were analysed. Serum concentrations of inhibin B, IGF-1, cortisol, prolactin, T4, thyroid-stimulating hormone (TSH), testosterone and LH were determined. In rats, administration of metandienone, estradienedione and S-1 resulted in an increase of muscle fiber diameter. Metandienone and estradienedione but not S-1 administration significantly decreases LH and inhibin B serum concentration....Continue Reading

References

Dec 1, 1988·International Journal of Sports Medicine·K HäkkinenP V Komi
Jul 1, 1987·The American Journal of Sports Medicine·M AlènR Vihko
May 31, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S M RothM A Rogers
Aug 17, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M F Wesche, W M Wiersinga
Sep 7, 2002·International Journal of Sports Medicine·C SimschJ M Steinacker
Aug 21, 2004·Seminars in Reproductive Medicine·Anne E O'Connor, David M De Kretser
Feb 22, 2005·Cellular and Molecular Life Sciences : CMLS·S Vadakkadath Meethal, C S Atwood
Sep 22, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J M SteinackerY Liu
Sep 22, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G Mastorakos, M Pavlatou
Feb 17, 2007·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·George A KyriazisTheodore J Angelopoulos
Sep 25, 2007·Sports Medicine·René KoopmanLuc J C van Loon
Dec 7, 2007·Endocrine Reviews·Nira Ben-JonathanElizabeth W LaPensee
Jun 10, 2008·Current Cancer Drug Targets·Maurizio BossolaGiovan Battista Doglietto
Mar 19, 2009·The Journal of Clinical Endocrinology and Metabolism·Yiqun GuKangshou Yao
Apr 10, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Shalender Bhasin, Ravi Jasuja
Apr 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Vahid MahabadiChristina Wang
Sep 24, 2009·European Journal of Endocrinology·Gianluca PerseghinLivio Luzi
Mar 11, 2010·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Andreas BarthelGeorg Benker
May 7, 2010·Journal of Biomedicine & Biotechnology·Muhammad A Abdul-Ghani, Ralph A DeFronzo
Oct 21, 2010·The Physician and Sportsmedicine·Daniel W D West, Stuart M Phillips
Nov 1, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Bethan E PhillipsPhilip J Atherton
Nov 24, 2011·Steroids·Carlos Stocco
Dec 14, 2011·Journal of Neuroendocrinology·S Rojas VegaH K Strüder
Apr 17, 2012·Physiology·Anand Sitaram, Michael S Marks
May 25, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G PallafacchinaS Schiaffino
May 26, 2012·Frontiers in Physiology·Gregory C Bogdanis
Sep 11, 2012·British Journal of Clinical Pharmacology·Leigh Breen, Stuart M Phillips
Mar 5, 2013·The FEBS Journal·Laura García-PratPura Muñoz-Cánoves
Jun 29, 2013·The International Journal of Biochemistry & Cell Biology·O SchakmanJ P Thissen
Feb 5, 2014·Future Oncology·Reshmi Srinath, Adrian Dobs

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