Combined effects of anticancer drugs and new synthetic α-methylene-δ-lactones on MCF-7 cells

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Katarzyna GachAnna Janecka

Abstract

The search for novel drug candidates is a priority goal for cancer therapy. Natural products isolated from plants are often used as valuable leads for the synthesis of analogs with simpler structure. Two synthetic α-methylene-δ-lactones with chroman-2-one skeleton, designated DL-3 and DL-5, exhibiting strong cytotoxic activity against several cancer cell lines, have been tested alone and in combination with well-known anticancer drugs, 5-fluorouracil, oxaliplatin, and taxol, in breast cancer MCF-7 cells. Parthenolide, a plant-derived α-methylene-γ-lactone, was used as a positive control. The effects on cell proliferation, DNA damage, and apoptosis induction were evaluated. Neither of the tested compounds significantly enhanced the effects produced by taxol, but a strong synergistic effect was observed with 5-fluorouracil and oxaliplatin. Only small differences between the actions of both α-methylene-δ-lactones were found. The synergistic effects produced by these compounds in MCF-7 cells were stronger as compared with parthenolide. Our findings show that simple and easy-to-obtain synthetic compounds with α-methylene-δ-lactone motif can potentiate the efficiency of anticancer drugs.

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Citations

Jun 6, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yang-Yang HanJin-Ming Gao
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz BartosikTomasz Janecki
May 31, 2019·Journal of Mass Spectrometry : JMS·Amauri Alves SouzaMaysa Furlan

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