Combined effects of NaCl and fluoxetine on the freshwater planarian, Schmidtea mediterranea (Platyhelminthes: Dugesiidae)

Environmental Science and Pollution Research International
Pearl U OfoegbuJoão L T Pestana

Abstract

Increasing salinity levels in freshwaters due to natural and anthropogenic sources pose risk to exposed aquatic organisms. However, there is a paucity of information on how salinity may influence the effects of other chemical stressors especially psychiatric pharmaceuticals. Freshwater planarians which have been suggested as bioindicator species in aquatic habitats were used in this study to evaluate toxic effects of sodium chloride (NaCl) used here as a surrogate for increasing salinity, and its influence on the effects of the antidepressant, fluoxetine. Effects of NaCl on Schmidtea mediterranea were evaluated using survival, regeneration, locomotion, feeding, and reproduction as endpoints. Subsequently, combined effects of NaCl and fluoxetine on planarians' locomotion and reproduction were also evaluated. Result showed that exposure to increased NaCl concentrations is toxic to planarians with 48 and 96 h LC50 of 9.15 and 7.55 g NaCl L-1 respectively and exposure to sub-lethal concentrations led to reductions in feeding (LOEC of 0.75 g NaCl L-1 or 1906 μS cm-1 at 20 °C) and reproduction (LOEC 3.0 g NaCl L-1 or 5530 μS cm-1 at 20 °C), delayed head regeneration (LOEC of 1.5 g NaCl L-1 or 3210 μS cm-1 at 20 °C), and also slight d...Continue Reading

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Citations

Jul 6, 2019·Médecine sciences : M/S·Laetitia PoirierÉric Chabrière
Jun 20, 2020·Environmental Science and Pollution Research International·Aline Silvestre Pereira DornelasJoão L T Pestana
Sep 17, 2021·Environmental Science and Pollution Research International·Laila Cristina Rezende SilvaRenato Almeida Sarmento
Oct 10, 2021·Biological Reviews of the Cambridge Philosophical Society·Cátia VenâncioIsabel Lopes

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