Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: a hospital based case-control study in China

Cancer Epidemiology
Yongtang JinYingchun Xu

Abstract

The limited information for effects of serum trace elements and genetic polymorphisms on lung cancer is available. Based on a hospital based case-control study, the epidemiological questionnaires were completed by face to face interview, and the gene polymorphisms were tested by RFLP-PCR, and serum trace metals were measured by atomic absorption spectrophotometer, and the data was analyzed by the logistic regressive models. The high serum copper level (>1500 ng/ml) or serum copper/zinc ratio (>1) was the risk factors of NSCLC (OR=3.10, 11.03, respectively), but the ORs of the higher serum Zn (>1200 ng/ml), Se (>50 ng/ml) or Cr(3+) (>600 ng/ml) for NSCLC were all significantly less than 0.20 (all p<0.01) indicating strong protection against NSCLC. While the OR of CYP 1A1 variants carriers with a higher serum Cu or Cu/Zn ratio level was around 3.38 and 12.59, respectively, the risk of CYP1A1 variants carriers with a higher serum Zn is 0.18, Se 0.04 or Cr(3+) 0.28. Similarly, compared with the carriers of GSTM1 power with a lower serum Zn, Se or Cr(3+), the OR of the carriers of GSTM1 null with a higher serum Zn, Se and Cr(3+) was separately 0.16, 0.07 and 0.26, highlighting the protection against NSCLC. Our findings suggested tha...Continue Reading

References

Jan 1, 1989·Oncology·M DíezJ L Balibrea
Feb 15, 1989·Cancer·M DìezJ L Balibrea
Jun 11, 1997·International Journal of Cancer. Journal International Du Cancer·J HuY Yang
Nov 16, 2004·The Journal of Nutritional Biochemistry·Emily Ho
Aug 23, 2005·Molecular Aspects of Medicine·Janet Y Uriu-Adams, Carl L Keen
Oct 14, 2005·Epidemiology·Wei ZhouDavid C Christiani
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Somdat MahabirMichele R Forman
Apr 4, 2007·The British Journal of Nutrition·Anne-Marie RousselRichard A Anderson
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mitsuo SatoJohn D Minna
Sep 29, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xiuquan ShiZengzhen Wang
Nov 1, 2007·Chemical Research in Toxicology·Konstantin Salnikow, Anatoly Zhitkovich
Dec 19, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Somdat MahabirQingyi Wei
Aug 30, 2008·Cancer Science·Masaaki Murakami, Toshio Hirano
Mar 18, 2009·Biochimica Et Biophysica Acta·Pin Zhuo, Alan M Diamond

❮ Previous
Next ❯

Citations

Aug 21, 2013·Critical Reviews in Food Science and Nutrition·Nicola M LoweVictoria Hall-Moran
Jun 19, 2014·PloS One·Jaromir GumulecRene Kizek
Sep 1, 2018·Metallomics : Integrated Biometal Science·Belén Callejón-LeblicTamara García-Barrera
Oct 10, 2018·The Journal of International Medical Research·Xiaping Zhang, Qun Yang
May 8, 2019·World Journal of Surgical Oncology·Ying WangYongsheng Zhang
Feb 15, 2019·International Journal of Molecular Sciences·Belén Callejón-LeblicTamara García-Barrera

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.