Abstract
Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the second one was daily gavaged with a saline solution of ethanol (4 g/kg, 4 weeks), and the last group was simultaneously exposed to both toluene and ethanol. Auditory function was tested by recording brain stem (inferior colliculus) auditory-evoked potentials for audiometric frequencies ranging from 2 to 32 kHz. Urinary hippuric acid was dosed to check the toluene metabolism during the experiments. Ethanol clearly modified the toluene metabolism in the present experimental conditions. As a result, the hearing loss induced by a simultaneous exposure to both ethanol and toluene was larger than that induced by exposure to toluene alone.
References
Jul 1, 1991·Brain Research Bulletin·G PryorR Gordon
Feb 1, 1991·Hearing Research·M Müller
Sep 1, 1990·Alcohol·S E LukasL Amass
Feb 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·F A MithenR Birchem
Mar 1, 1990·Hearing Research·C A ProsenJ E Hawkins
Jan 1, 1987·Pharmacology & Therapeutics·D W CrabbT K Li
Jan 1, 1987·Journal of Studies on Alcohol·J B Spitzer, C W Newman
Sep 1, 1985·Pharmacology, Biochemistry, and Behavior·G T PryorA B Thurber
Dec 1, 1984·Toxicology and Applied Pharmacology·M WallénM B Nordqvist
Jan 1, 1983·International Archives of Occupational and Environmental Health·H A WaldronJ D Johnston
Nov 1, 1980·British Journal of Industrial Medicine·A SatoY Koyama
Aug 1, 1981·Toxicology and Applied Pharmacology·A SatoY Koyama
Feb 1, 1995·Pharmacology & Toxicology·P NylénA C Johnson
Mar 1, 1993·Hearing Research·B J Dannhof, V Bruns
Citations
Sep 9, 2000·Hearing Research·G LoquetP Bonnet
Jul 1, 1999·Neurotoxicology and Teratology·R LatayeG Loquet
Nov 24, 1999·Neurotoxicology and Teratology·G LoquetR Lataye
Jul 29, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Delphine WaniusiowCécile Parietti-Winkler
Apr 4, 2006·Environmental Health Perspectives·Ania Mendoza-CantúArnulfo Albores
Jun 9, 2007·Hearing Research·Robert LatayePierre Campo
Apr 19, 2008·Neurotoxicology and Teratology·Delphine WaniusiowLuc Ferrari
May 13, 2008·International Journal of Occupational Medicine and Environmental Health·Søren P Lund, Gitte B Kristiansen
Dec 28, 2007·Neurotoxicology and Teratology·Pierre CampoManuella Burgart
Nov 9, 2011·Toxicology and Industrial Health·A VyskocilC Viau
Feb 9, 2008·Critical Reviews in Toxicology·Perrine Hoet, Dominique Lison
Aug 8, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Frédéric CosnierPierre Campo
Nov 27, 2014·Frontiers in Neural Circuits·Feixue LiangZhongju Xiao
Mar 12, 2005·Journal of Occupational and Environmental Medicine·Laura R KaufmanPaul Succop
Jul 10, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M I BantonS S Sarang