Combined Effects of Suberoylanilide Hydroxamic Acid and Cisplatin on Radiation Sensitivity and Cancer Cell Invasion in Non-Small Cell Lung Cancer

Molecular Cancer Therapeutics
Jianguo FengShenglin Ma

Abstract

Lung cancer is a leading cause of cancer-related mortality worldwide, and concurrent chemoradiotherapy has been explored as a therapeutic option. However, the chemotherapeutic agents cannot be administered for most patients at full doses safely with radical doses of thoracic radiation, and further optimizations of the chemotherapy regimen to be given with radiation are needed. In this study, we examined the effects of suberoylanilide hydroxamic acid (SAHA) and cisplatin on DNA damage repairs, and determined the combination effects of SAHA and cisplatin on human non-small cell lung cancer (NSCLC) cells in response to treatment of ionizing radiation (IR), and on tumor growth of lung cancer H460 xenografts receiving radiotherapy. We also investigated the potential differentiation effect of SAHA and its consequences on cancer cell invasion. Our results showed that SAHA and cisplatin compromise distinct DNA damage repair pathways, and treatment with SAHA enhanced synergistic radiosensitization effects of cisplatin in established NSCLC cell lines in a p53-independent manner, and decreased the DNA damage repair capability in cisplatin-treated primary NSCLC tumor tissues in response to IR. SAHA combined with cisplatin also significantl...Continue Reading

References

Nov 1, 1994·International Journal of Radiation Biology·J F Ward
Mar 1, 1994·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T Le ChevalierA Laplanche
Oct 17, 2003·The Journal of Biological Chemistry·Neelam TanejaRalph R Weichselbaum
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Kerstin BorgmannEkkehard Dikomey
Nov 19, 2004·Nature·Michael B Kastan, Jiri Bartek
May 12, 2005·Molecular Cancer Research : MCR·Heather J BoeckmanJohn J Turchi
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chandra P BelaniWalter J Curran
Feb 18, 2006·Nature Reviews. Drug Discovery·Christine B Yoo, Peter A Jones
May 2, 2006·International Journal of Radiation Oncology, Biology, Physics·Feng-Ming KongRandall K Ten Haken
Apr 12, 2007·Critical Reviews in Oncogenesis·Jeroen de Jong, Leendert H J Looijenga
Apr 13, 2007·Expert Review of Anticancer Therapy·Douglas Marchion, Pamela Münster
Sep 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A William Blackstock, Ramaswamy Govindan
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Giulia BertoliniGabriella Sozzi
Jan 7, 2010·BMC Cancer·Judit P BanáthPeggy L Olive
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Jun 18, 2010·The Cochrane Database of Systematic Reviews·Noelle O'RourkeFergus Macbeth
Feb 1, 2011·Journal of Gynecologic Oncology·Ke Long JinJoo-Hyun Nam
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Akira Mogi, Hiroyuki Kuwano
Jun 14, 2012·Clinical & Developmental Immunology·Appalaraju Jaggupilli, Eyad Elkord
Jul 10, 2012·Seminars in Cancer Biology·Katia Sampieri, Riccardo Fodde
Aug 8, 2012·The Journal of Cell Biology·Irène Baccelli, Andreas Trumpp
Jan 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Valeria CarinaCarla Giordano
Mar 19, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Noemi ReguartMiquel Taron
Jun 21, 2014·Future Oncology·Mark R KelleyMelissa L Fishel

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Citations

Feb 8, 2018·International Journal of Molecular Sciences·Ariungerel GerelchuluunTakamitsu A Kato
Jul 10, 2018·BioMed Research International·Yao DongFeng Jianguo
Nov 29, 2017·BioMed Research International·Jiang RuibinGu Linhui

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