Combined effects of systolic blood pressure and serum cholesterol on cardiovascular mortality in young (<55 years) men and women

European Heart Journal
F ThomasA Benetos

Abstract

To evaluate the combined effects of the two most frequent modifiable risk factors, systolic blood pressure and serum cholesterol, on cardiovascular and coronary mortality, in a large French population aged 18 to 55 years. We studied 108,879 men (mean age 39.1+/-9.4 years) and 84,931 women (mean age 37.3+/-10.0 years) who had a health check-up at the IPC Center between 1978 and 1988. Mortality data for a mean period of 13 years were analysed. Systolic blood pressure and cholesterol levels were classified according to the cut-points proposed by international guidelines. In men, the prevalence of high cholesterol was more than twice as high in hypertensives as in normotensives; in women, it was more than three times higher. The combination of these two risk factors has additive effects on cardiovascular disease and coronary heart disease risk. In men, a borderline elevation of both systolic blood pressure (130-139 mmHg) and cholesterol (200-239 mg x dl(-1)) leads to a three- to four-fold increase in cardiovascular disease risk. Men with systolic blood pressure >or=160 mmHg represent a small percentage (about 5%) who have a 10-fold increase in cardiovascular disease and coronary heart disease risk, especially when high cholesterol ...Continue Reading

Citations

Nov 16, 2007·Journal of Neurology·J RoquerJ E Martínez-Rodríguez
Dec 19, 2007·Pharmaceutical Research·R Preston MasonTadeusz Malinski
Jul 20, 2004·Current Hypertension Reports·Maurizio Cesari, Achille C Pessina
May 16, 2003·Lancet·Jan A StaessenWillem H Birkenhäger
Aug 21, 2002·Current Opinion in Nephrology and Hypertension·Claudio Borghi
Nov 26, 2009·Patient Preference and Adherence·Richard H ChapmanCraig S Roberts
Oct 24, 2007·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Verna Welch, Simon S K Tang
Jun 16, 2014·Metabolism: Clinical and Experimental·Bronwyn G A StuckeyValerie Burke
Nov 13, 2012·Expert Opinion on Pharmacotherapy·Antonia Delgado-Montero, Jose L Zamorano
Oct 9, 2007·Current Medical Research and Opinion·Thomas M MacDonaldEssy Mozaffari
Jun 23, 2005·Current Medical Research and Opinion·Jacobus T van WykMiriam C J M Sturkenboom
Jul 3, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Maksim ZaguraMihkel Zilmer
Jun 23, 2006·Revista española de cardiología·Carlos A PaternoJuan C Giménez
Sep 6, 2008·The Journal of Clinical Hypertension·Roland E Schmieder, Luis M Ruilope
Sep 6, 2007·The Journal of Clinical Hypertension·Michael P DutroGeorge A Goldberg
May 6, 2008·The Journal of Clinical Hypertension·John B KostisUNKNOWN Treating to New Targets Steering Committee and Investigators
Aug 10, 2006·The Journal of Clinical Hypertension·Franz H MesserliUNKNOWN AVALON Investigators
Dec 17, 2005·The American Journal of Medicine·R Preston Mason
Jan 2, 2007·The American Journal of Cardiology·Vincent E FriedewaldWilliam C Roberts
Aug 7, 2007·The American Journal of Medicine·Sripal BangaloreFranz H Messerli
Jan 14, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Michael B NicholMohamed Hussein
Oct 18, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C BorghiA F Cicero
Dec 20, 2008·The Journal of International Medical Research·J ZamoranoUNKNOWN CORONARIA Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.