PMID: 8986455Dec 1, 1996Paper

Combined effects of the angiotensin II antagonist candesartan cilexetil (TCV-116) and other classes of antihypertensive drugs in spontaneously hypertensive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
T WadaY Inada

Abstract

The antihypertensive effects of an angiotensin II antagonist, candesartan cilexetil (TCV-116), and other classes of antihypertensive drugs (including a calcium antagonist, manidipine; a diuretic, hydrochlorothiazide (HCTZ); an alpha-blocker, prazosin; and a beta-blocker, atenolol) administered in combination were examined in spontaneously hypertensive rats by oral administration daily for 2 wk. TCV-116 at 1 mg/kg lowered the blood pressure by about 50 and 30 mmHg, 5 and 24 h after dosing, respectively. The blood pressure was slightly lowered by HCTZ at 10 mg/kg, but it was synergistically reduced when HCTZ was given in combination with TCV-116. Manidipine at 3 mg/kg lowered the blood pressure by about 50 mmHg 1 h after administration. When manidipine was given in combination with TCV-116, blood pressure was reduced additively. Prazosin at 1 mg/kg lowered the blood pressure by 40 to 50 mmHg 1 h after dosing. When prazosin was given in combination with TCV-116, the reduction was intensified more than additively, to about 100 mmHg. Atenolol at 50 mg/kg lowered the blood pressure by 10 to 20 mmHg 5 h after dosing. Even when atenolol was administered in combination with TCV-116, the reduction in blood pressure was virtually the same...Continue Reading

Citations

Oct 10, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bruno IgrejaPatrício Soares-da-Silva
Aug 1, 2006·American Journal of Hypertension·Wen-Ze WangPhilip Palade
Oct 8, 1999·Journal of Cardiovascular Pharmacology·H EbisuN Nakamura
Jan 12, 2000·The Annals of Pharmacotherapy·C A StoukidesA F Kaul

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