Combined Efficacy of Gallic Acid and MiADMSA with Limited Beneficial Effects Over MiADMSA Against Arsenic-induced Oxidative Stress in Mouse

Biochemistry Insights
Vidhu Pachauri, Sjs Flora

Abstract

Gallic acid is an organic acid known for its antioxidant and anticancer properties. The present study is focused on evaluating the role of gallic acid in providing better therapeutic outcomes against arsenic-induced toxicity. Animals pre-exposed to arsenic were treated with monoisoamyl meso-2,3-dimercaptosuccinic acid (MiADMSA), a new chelating drug, alone and in combination with gallic acid, consecutively for 10 days. The study suggests that (1) gallic acid in presence of MiADMSA is only moderately beneficial against arsenic, (2) monotherapy with gallic acid is more effective than in combination with MiADMSA after arsenic exposure in reducing oxidative injury, and (3) MiADMSA monotherapy as reported previously provides significant therapeutic efficacy against arsenic. Thus, based on the present results, we conclude that gallic acid is effective against arsenic-induced oxidative stress but provides limited additional beneficial effects when administered in combination with MiADMSA. We still recommend that lower doses of gallic acid be evaluated both individually and in combination with MiADMSA, as it might not exhibit the shortcomings we observed with higher doses in this study.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J M McCordI Fridovich
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Jan 1, 1984·Methods in Enzymology·H Aebi
Sep 21, 2000·Toxicology·M TravacioS Llesuy
Sep 18, 2001·Biological & Pharmaceutical Bulletin·K IsuzugawaY Ogihara
Jan 22, 2004·Journal of Agricultural and Food Chemistry·Yusuf Yilmaz, Romeo T Toledo
Feb 20, 2004·Molecular and Cellular Biochemistry·Honglian ShiKe Jian Liu
Jun 2, 2007·Biological & Pharmaceutical Bulletin·You-Jung Kim
Jan 10, 2008·Biological Trace Element Research·Deepshikha Mishra, S J S Flora
Jan 17, 2008·Archives of Toxicology·Prasenjit MannaParames C Sil
Feb 15, 2008·Journal of Biochemical and Molecular Toxicology·Mahua SinhaParames C Sil
Dec 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G Sharmila BanuA G Murugesan
Jun 18, 2010·European Journal of Pharmacology·Yong LuShing-Shun Tony To
Aug 19, 2010·International Journal of Environmental Research and Public Health·Swaran J S Flora, Vidhu Pachauri
Feb 8, 2011·Journal of Clinical Biochemistry and Nutrition·Dharmendra K MauryaThomas Paul Asir Devasagayam
May 11, 2011·Free Radical Biology & Medicine·Swaran J S Flora
Oct 12, 2011·Metallomics : Integrated Biometal Science·Swaran J S FloraNidhi Dwivedi
Jan 10, 2012·Pharmacognosy Research·Snehal S Patel, Ramesh K Goyal

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Citations

Sep 8, 2018·Physical Chemistry Chemical Physics : PCCP·Giuseppe CassoneFranz Saija
Oct 19, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saba NaqviS J S Flora
Aug 6, 2021·Drug and Chemical Toxicology·Sherry SachdevaS J S Flora

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