Combined evaluation of conventional MRI, dynamic contrast-enhanced MRI and diffusion weighted imaging for response evaluation of patients with multiple myeloma

European Journal of Radiology
Julie C DutoitKoenraad L Verstraete

Abstract

To evaluate the value of the combined evaluation of SE MRI, dynamic contrast enhanced MRI (DCE-MRI) and diffusion weighted imaging (DWI) in multiple myeloma (MM) patients after treatment compared to the international myeloma working group (IMWG) response criteria. The retrospective study includes 27 newly diagnosed patients, providing 99 MRI-investigations. Patients were categorized according to the IMWG response criteria. Quantitative assessment was based on signal intensities (SI) of T1-weighted, fat-saturated T2-weighted and b1000 images, apparent diffusion coefficients (ADC) and parameters from time-intensity-curves (TIC) derived from L3. Qualitative visual analysis of conventional MRI-images, b1000-images and TICs, providing a "combined skeletal score", was used to create MRI response criteria. The combined skeletal score could significantly differentiate between subgroups based on IMWG response criteria (p=0.016). The gold standard plasmacytosis could significantly differentiate between subgroups based on MRI response criteria (p<0.001), as well as slope (p<0.001) and ADC (p=0.006). There is a good agreement between IMWG and MRI response criteria (Kendall's coefficient=0.761). Response evaluation of MM-patients based on t...Continue Reading

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Citations

May 12, 2016·Insights Into Imaging·Julie C Dutoit, Koenraad L Verstraete
Jun 15, 2016·Journal of Magnetic Resonance Imaging : JMRI·Xiao-Quan XuFei-Yun Wu
Jul 14, 2016·Expert Review of Hematology·E ZamagniM Cavo
Jan 4, 2019·The British Journal of Radiology·Tara BarwickChristina Messiou
Dec 28, 2018·Blood·Elena ZamagniMichele Cavo
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Evangelos TerposLia A Moulopoulos
Jan 31, 2020·PloS One·Saurabh SinghMargaret A Hall-Craggs
Feb 1, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Ho Young ParkDok Hyun Yoon
Dec 3, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Esther G M de WaalRiemer H J A Slart
Aug 23, 2018·Frontiers in Endocrinology·Barry G Hansford, Rebecca Silbermann
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Elena ZamagniDavid Roodman
Feb 3, 2018·The British Journal of Radiology·Vassilis KoutoulidisLia A Moulopoulos
Aug 6, 2020·International Journal of Molecular Sciences·Bastien JametFrançoise Kraeber-Bodere
Apr 22, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenneth C AndersonElena Zamagni
Aug 29, 2020·Magnetic Resonance Imaging·Louis MarageHervé Saint-Jalmes
Nov 5, 2020·Journal of Clinical Medicine·Elena ZamagniMichele Cavo
Aug 28, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Koeun LeeHye Won Chung

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