Abstract
In order to estimate the prognostic values of p27(Kip1), p21(Waf1/Cip1), and p53, alone and in combination, we investigated immunohistochemically the expression of p27(Kip1), p21(Waf1/Cip1), and p53 proteins in gastric carcinomas. The expression of p27(Kip1), p21(Waf1/Cip1), and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27(Kip1) and p21(Waf1/Cip1) correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27(Kip1) expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21(Waf1/Cip1) and p27(Kip1). The mortality rate was higher in patients with both p21(Waf1/Cip1)- and p27(Kip1)-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21(Waf1/Cip1)/p27(Kip1) groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Our results suggest that low express...Continue Reading
References
Sep 1, 1992·British Journal of Cancer·T StarzynskaP L Stern
Mar 1, 1990·American Journal of Clinical Pathology·J W SaidG S Pinkus
Jan 1, 1991·Cytometry·I SchmidJ V Giorgi
Jul 5, 1991·Science·M HollsteinC C Harris
Mar 24, 1990·Lancet·R IggoA L Harris
Jun 1, 1988·Cancer·L H SobinR V Hutter
Apr 1, 1995·Molecular Biology of the Cell·J W HarperE Swindell
Nov 18, 1994·Cell·C J Sherr
Nov 18, 1994·Cell·T Hunter, J Pines
May 1, 1994·British Journal of Cancer·B V JoypaulA Cuschieri
Feb 1, 1997·Nature Medicine·C CatzavelosJ M Slingerland
Feb 1, 1997·Nature Medicine·M LodaM Pagano
Mar 1, 1997·Nature Medicine·A M ChinnaiyanG J Nabel
Jun 1, 1997·Nature Medicine·M MoriT Akiyoshi
Aug 15, 1997·Cancer·T KakuH Nakano
Nov 14, 1997·Cancer·L H Sobin, I D Fleming
Feb 26, 1998·American Journal of Respiratory Cell and Molecular Biology·M CaputiA Giordano
May 20, 1998·Digestive Diseases and Sciences·M IkeguchiN Kaibara
Aug 26, 1998·Molecular Pathology : MP·A G CassonH Ozcelik
Sep 10, 1998·Journal of the National Cancer Institute·C Cordon-CardoH I Scher
Sep 19, 1998·Journal of Korean Medical Science·S J JangJ D Lee
Nov 5, 1999·The Journal of Pathology·W MüllerH E Gabbert
Feb 10, 2000·The American Journal of Pathology·Y TakanoI Okayasu
Mar 17, 2001·Cancer·S KawauchiK Sasaki
Jan 1, 1965·Acta Pathologica Et Microbiologica Scandinavica·P LAUREN
Citations
Dec 16, 2006·Digestive Diseases and Sciences·Tetsuya TanigawaAndrzej S Tarnawski
Jun 18, 2003·Journal of Clinical Gastroenterology·Runjan Chetty, UNKNOWN University Health Network, Princess Margaret Hospital, 610 University Avenue, Fourth Floor, Suite 302 Toronto, ON M5G 2M9, C
Jan 15, 2008·Pancreas·Yutaka SuzukiYutaka Atomi
May 8, 2007·Journal of Clinical Pathology·Armando Gamboa-DominguezBirgit Luber
Jun 8, 2010·BMC Gastroenterology·Tamotsu SugaiKazuyuki Suzuki
Feb 9, 2008·Cancer Investigation·Yu Jung KimYung-Jue Bang
Jun 15, 2010·Cancer Epidemiology·Angela Rosa AndréSílvia Helena Barem Rabenhorst
Mar 26, 2010·Human Pathology·Maria D BegnamiFernando A Soares
Aug 27, 2005·Journal of Surgical Oncology·M S Al-MoundhriC Grant
Jul 10, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Jung-Ta KaoTsung-Hui Hu
Feb 17, 2006·Journal of Surgical Oncology·Gennaro GaliziaFerdinando De Vita
Feb 24, 2010·International Journal of Cancer. Journal International Du Cancer·Tamotsu SugaiKazuyuki Suzuki
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·Yoshiyuki SuzukiKuniyuki Oka
Nov 16, 2005·Gastroenterology·Noriyoshi KuzushitaSteven F Moss
Jun 15, 2007·Molecular Cancer·Pabbisetty Sudheer KumarPadma Shastry
Dec 13, 2006·Arquivos De Gastroenterologia·Maitê de Mello VillwockCarlos Cauduro Schirmer
Sep 26, 2006·Journal of Cellular Physiology·Eliseo MattioliPier Paolo Claudio
Apr 3, 2002·Japanese Journal of Cancer Research : Gann·Xiu Ping LiuKohsuke Sasaki
Feb 23, 2018·Molecular and Clinical Oncology·Roberson A MoronBruno Zilberstein
Mar 6, 2003·Human Mutation·C M Fenoglio-PreiserA Noffsinger
Mar 8, 2006·World Journal of Gastroenterology : WJG·Pei-Hong JiangNorio Sawabu
Apr 8, 2004·World Journal of Gastroenterology : WJG·Hai-Long XieYi-Qin Li
Sep 25, 2007·Onkologie·Luo YiTang Xuanbing
Mar 20, 2018·Oncotarget·Dan-Dan XiongYi-Wu Dang
Mar 23, 2017·Journal of Gastroenterology·Takahito TobaShu Hoteya
May 16, 2021·Surgical Oncology·Pavneet KohliA Balasubramanian