Combined examination of p27(Kip1), p21(Waf1/Cip1) and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma

Histopathology
X P LiuK Sasaki

Abstract

In order to estimate the prognostic values of p27(Kip1), p21(Waf1/Cip1), and p53, alone and in combination, we investigated immunohistochemically the expression of p27(Kip1), p21(Waf1/Cip1), and p53 proteins in gastric carcinomas. The expression of p27(Kip1), p21(Waf1/Cip1), and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27(Kip1) and p21(Waf1/Cip1) correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27(Kip1) expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21(Waf1/Cip1) and p27(Kip1). The mortality rate was higher in patients with both p21(Waf1/Cip1)- and p27(Kip1)-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21(Waf1/Cip1)/p27(Kip1) groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Our results suggest that low express...Continue Reading

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Citations

Dec 16, 2006·Digestive Diseases and Sciences·Tetsuya TanigawaAndrzej S Tarnawski
Jun 18, 2003·Journal of Clinical Gastroenterology·Runjan Chetty, UNKNOWN University Health Network, Princess Margaret Hospital, 610 University Avenue, Fourth Floor, Suite 302 Toronto, ON M5G 2M9, C
May 8, 2007·Journal of Clinical Pathology·Armando Gamboa-DominguezBirgit Luber
Jun 15, 2010·Cancer Epidemiology·Angela Rosa AndréSílvia Helena Barem Rabenhorst
Jul 10, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Jung-Ta KaoTsung-Hui Hu
Feb 24, 2010·International Journal of Cancer. Journal International Du Cancer·Tamotsu SugaiKazuyuki Suzuki
Dec 13, 2006·Arquivos De Gastroenterologia·Maitê de Mello VillwockCarlos Cauduro Schirmer
Apr 3, 2002·Japanese Journal of Cancer Research : Gann·Xiu Ping LiuKohsuke Sasaki
Feb 23, 2018·Molecular and Clinical Oncology·Roberson A MoronBruno Zilberstein
Mar 6, 2003·Human Mutation·C M Fenoglio-PreiserA Noffsinger
Mar 8, 2006·World Journal of Gastroenterology : WJG·Pei-Hong JiangNorio Sawabu
Apr 8, 2004·World Journal of Gastroenterology : WJG·Hai-Long XieYi-Qin Li

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