Combined exposure to low doses of pesticides causes decreased birth weights in rats

Reproductive Toxicology
Ulla HassJulie Boberg

Abstract

Decreased birth weight is a common effect of many pesticides in reproductive toxicity studies, but there are no empirical data on how pesticides act in combination on this endpoint. We hypothesized that a mixture of six pesticides (cyromazine, MCPB, pirimicarb, quinoclamine, thiram, and ziram) would decrease birth weight, and that these mixture effects could be predicted by the Dose Addition model. Data for the predictions were obtained from the Draft Assessment Reports of the individual pesticides. A mixture of equi-effective doses of these pesticides was tested in two studies in Wistar rats, showing mixture effects in good agreement with the additivity predictions. Significantly lower birth weights were observed when compounds were present at individual doses below their no-observed adverse effect levels (NOAELs). These results emphasize the need for cumulative risk assessment of pesticides to avoid potentially serious impact of mixed exposure on prenatal development and pregnancy in humans.

Citations

Jul 15, 2017·Toxicology Mechanisms and Methods·Ying SuRen-Shan Ge
Oct 5, 2019·International Journal of Environmental Research and Public Health·Leah Zilversmit PaoPierre Buekens
Jan 3, 2021·Environmental Science and Pollution Research International·Baskar VenkidasamyMuthu Thiruvengadam

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