PMID: 9169813Mar 15, 1997Paper

Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate

International Journal of Radiation Oncology, Biology, Physics
M S AnscherM W Dewhirst

Abstract

To determine the safety and efficacy of combined external beam irradiation and external regional hyperthermia in the treatment of adenocarcinoma of the prostate. From 1987 to 1994, 30 patients received combined external beam irradiation and external regional hyperthermia for locally advanced prostate cancer. The results of the 21 patients with newly diagnosed (n = 18) or locally recurrent (n = 3) adenocarcinoma are reported herein. No patient had evidence of distant metastases. Total radiotherapy doses of 65-70 Gy to the prostate were planned using a four-field box technique. Hyperthermia treatments were delivered using an annular phased array microwave device. The treatment goal was to achieve temperatures > or = 42 degrees C in all measured points within the prostate. Of the newly diagnosed patients, 16 out of 18 (89%) had T3 or T4 tumors, 11 out of 18 (61%) had Gleason scores of 7-9, and the mean pretreatment Prostate Specific Antigen (PSA) was 69 ng/ml. The median follow-up of all 21 patients was 36 months. None of the patients achieved the treatment goal of all intratumoral temperatures > or = 42 degrees C. The mean CEM 43 T90 was 2.34 min. The disease-free survival at 36 months is 25%; 12 out of 18 (67%) of the patients h...Continue Reading

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Citations

Apr 10, 1999·Urology·C LancasterJ Trachtenberg
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·F LohrC Y Li
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Marco van VulpenJan J Battermann
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Nov 19, 2003·Journal of Endourology·Stavros GravasJean J M C H De La Rosette
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Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·H Petra KokArjan Bel
May 21, 2011·International Journal of Pharmaceutics·Hui ZhangWan-liang Lv
Dec 15, 2004·Mayo Clinic Proceedings·Michael D GillettMichael L Blute
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Nov 4, 2010·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sergio MalutaLuisa Nadalini
Jan 17, 2015·Cancer Letters·Suresh J HaikerwalNicole M Haynes
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Jul 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Burghard Thiesen, Andreas Jordan
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