Combined external beam radiotherapy and Pd-103 brachytherapy boost improves biochemical failure free survival in patients with clinically localized prostate cancer: results of a matched pair analysis

The Prostate
Anu M SinghAnatoly Dritschilo

Abstract

Dose escalation has resulted in improved biochemical control in patients with clinically localized prostate cancer treated with conformal external beam radiation (EBRT). Conformal dose distributions may also be achieved with brachytherapy. Therefore, biochemical control was evaluated for patients treated with combined external radiation therapy and low dose rate brachytherapy (EBRT + LDR). A matched pair analysis was performed to compare biochemical control of patients treated with EBRT + LDR to patients treated with EBRT alone. The study endpoints were biochemical control and late toxicities. The 5-year biochemical failure free survival (BFFS) was 86% for patients treated with EBRT + LDR and 72% for patients treated with EBRT (P = 0.03). Both treatments were associated with comparable incidences of late genitourinary (GU) side effects (18-19%). Late rectal toxicity was decreased by 15% in patients treated with EBRT + LDR (P = 0.0003). These results support EBRT followed by brachytherapy boost as a safe and effective method for dose escalation in the treatment of prostate cancer.

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Citations

Jun 15, 2007·Prostate Cancer and Prostatic Diseases·C Greco
Sep 15, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bradley R PietersAeilko H Zwinderman
May 16, 2009·Surgical Oncology·Russell N Moule, Peter J Hoskin
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Frank PeinemannStefan Sauerland

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