Combined factor V and factor VII deficiency. Report of a case with a record on combined defects and considerations on the relevance of partial deficiency of coagulation factors

Acta Haematologica
B RotoliF Chiurazzi

Abstract

A patient suffering from cardiochalasia was found to be partially deficient in both coagulation factors V and VII. No bleeding tendency had been noticed. A family study showed that the father had factor VII deficiency with normal factor V, while the mother and 2 sisters had a reduced level of factor V and normal factor VII. Thus, the combined deficiency was due to chance association of two distinct independently segregating genetic defects. While a number of combinations of coagulation factor deficiency have been previously described, this, to be best of our knowledge, is the first instance of combined deficiency of factor V and VII reported so far.

Citations

Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·A GirolamiM Fadin
Nov 11, 2006·Acta Haematologica·A GirolamiS Vettore
Apr 17, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·H MansouritorgabehH Esamaili
Aug 8, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Chiduko YasunagaYoh Hidaka
Sep 13, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Majid NaderiAkbar Dorgalaleh
Jul 1, 1996·American Journal of Hematology·A S SallahH R Roberts
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M T SartoriA Girolami
Sep 30, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·S ShettyD Mohanty
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Ingerslev, H L Kristensen
May 28, 2004·Indian Journal of Pediatrics·Jagruti P SanghviRamesh C Parmar

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