Combined findings of FDG-PET and arterial spin labeling in sporadic Creutzfeldt-Jakob disease

Prion
Junliang YuanWenli Hu

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal progressive neurodegenerative disease. Multimodal approaches, including electroencephalogram, diffusion-weighted imaging (DWI) of brain MRI, and cerebrospinal fluid biomarkers, have been applied to increase the diagnostic accuracy of sCJD. Although previous studies suggested DWI could be the most useful modality for sCJD diagnosis, whether metabolism changes underlying in sCJD are still poorly understood. To the best of our knowledge, there are only one case using the technique of arterial spin labeling (ASL) to detection and follow-up of perfusion changes in CJD. Herein, we described a 71-year-old woman presented with progressive cognitive decline, behavioral and psychological symptoms for two months. The patient died one month later after her admission. As far as we know, this is the first report using the combination of fluorodeoxyglucose positron emission tomography and ASL to explore the metabolism changes in sCJD. Our case exemplifies the difficulty clinicians may face in the diagnosis of sCJD.

References

Dec 17, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Henry EnglerBengt Långström
Feb 25, 2005·Neurology·T HamaguchiM Yamada
Dec 18, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Nobuyuki OkamuraKatsumi Doh-ura
Nov 13, 2010·AJNR. American Journal of Neuroradiology·W-J ZhangC J Keary
Nov 5, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E-J KimY Jeong
Jul 17, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xiao-wei XingSheng-yuan Yu
Mar 4, 2014·Neurología : publicación oficial de la Sociedad Española de Neurología·S Ortega-CuberoM Riverol
Aug 15, 2014·Journal of the Neurological Sciences·Philipp EuskirchenJan Sobesky
Sep 16, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Shuai ChenJie-Wen Zhang
Jun 5, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Elena PrietoJavier Arbizu
Jul 3, 2015·Neurology. Clinical Practice·Sven A FornerMichael D Geschwind
Dec 29, 2016·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yasushi Iwasaki
Jan 12, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Diego Cardoso FragosoAntonio J da Rocha
Jan 26, 2017·Alzheimer Disease and Associated Disorders·Karin P MenteBrian S Appleby
Nov 4, 2017·Prion·Dimitri RenardVincent Boudousq
Apr 5, 2018·QJM : Monthly Journal of the Association of Physicians·J DuignanR P Killeen

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