Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus

Neural Plasticity
Silvia PogginiIgor Branchi

Abstract

An increasing number of studies show that selective serotonin reuptake inhibitors (SSRIs) exert their therapeutic action, at least in part, by amplifying the influence of the living environment on mood. As a consequence, when administered in a favorable environment, SSRIs lead to a reduction of symptoms, but in stressful conditions, they show limited efficacy. Therefore, novel therapeutic approaches able to neutralize the influence of the stressful environment on treatment are needed. The aim of our study was to test whether, in a mouse model of depression, the combined administration of SSRI fluoxetine and metformin, a drug able to improve the metabolic profile, counteracts the limited efficacy of fluoxetine alone when administered in stressful conditions. Indeed, metabolic alterations are associated to both the onset of major depression and the antidepressant efficacy. To this goal, adult C57BL/6 male mice were exposed to stress for 6 weeks; the first two weeks was aimed at generating a mouse model of depression. During the remaining 4 weeks, mice received one of the following treatments: vehicle, fluoxetine, metformin, or a combination of fluoxetine and metformin. We measured liking- and wanting-type anhedonia as behavioral ...Continue Reading

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Citations

Jun 6, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mahmoud S AbdallahAbla M Ebeid
Jan 29, 2021·Journal of Neuroendocrinology·Hugo MartinXavier Fioramonti
Sep 19, 2019·Journal of Agricultural and Food Chemistry·Francesca CaracciGiulio Maria Pasinetti

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Methods Mentioned

BETA
PCR
dissection

Software Mentioned

StatView
LightCycler® 480
Clampfit
pClamp
IntelliCage

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