Combined Gene Therapy Using AdsVEGFR2 and AdsTie2 With Chemotherapy Reduces the Growth of Human Ovarian Cancer and Formation of Ascites in Mice

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Laura TuppurainenSeppo Ylä-Herttuala

Abstract

Ovarian cancer is highly dependent on tumor microvessels and angiogenesis regulated by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) and angiopoietins (Ang) and their Tie receptors. We studied the efficacy of adenoviral (Ad) gene therapy with soluble VEGFR2 and Tie2 combined with paclitaxel and carboplatin for the treatment of ovarian cancer. An intraperitoneal human ovarian cancer xenograft model in nude mice (n = 44) was used in this study. Gene therapy was given intravenously when the presence of sizable tumors was confirmed in magnetic resonance imaging. The study groups were as follows: AdCMV as a control (group I), AdCMV with chemotherapy (group II), AdsVEGFR2 and AdsTie2 (group III), and AdsVEGFR2 and AdsTie2 with chemotherapy (group IV). Antitumor effectiveness was assessed by overall tumor growth, ascites, immunohistochemistry, microvessel density, and sequential magnetic resonance imaging analyses. AdsVEGFR2 and AdsTie2 gene therapy (group III) significantly reduced tumor weights as compared with group II (P = 0.007). Accumulation of ascites was significantly reduced when the mice were treated with AdsVEGFR2 and AdsTie2 gene therapy or with combined gene therapy and chemotherapy as compared ...Continue Reading

References

May 2, 2001·The Journal of Cell Biology·M HellströmC Betsholtz
Jun 5, 2003·Nature Medicine·Christopher W Pugh, Peter J Ratcliffe
Sep 4, 2003·Journal of the National Cancer Institute·Andreas du BoisUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Limin HuRobert B Jaffe
Sep 28, 2006·Journal of Biochemistry and Molecular Biology·Masabumi Shibuya
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A P M HeintzU Beller
Apr 9, 2008·American Journal of Obstetrics and Gynecology·Chunhua LuAnil K Sood
Dec 4, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hanna SallinenSeppo Yla-Herttuala
Dec 6, 2008·International Journal of Cancer. Journal International Du Cancer·Whitney A SpannuthAnil K Sood
May 19, 2009·Angiogenesis·Markus Thomas, Hellmut G Augustin
Mar 3, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sirin A I AdhamBrenda L Coomber
Dec 30, 2011·The New England Journal of Medicine·Robert A BurgerUNKNOWN Gynecologic Oncology Group
Dec 30, 2011·The New England Journal of Medicine·Timothy J PerrenUNKNOWN ICON7 Investigators
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 18, 2012·International Journal of Cancer. Journal International Du Cancer·Minna SopoSeppo Yla-Herttuala
Aug 2, 2013·International Journal of Molecular Sciences·Nikos G GavalasAristotle Bamias
Jul 22, 2014·The American Journal of Pathology·Melissa K BrunckhorstQin Yu
Aug 5, 2014·Cell Reports·Nicolò RigamontiMichele De Palma
Jul 2, 2015·Critical Reviews in Oncology/hematology·Angiolo GadducciClaudia Sergiampietri
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Apm HeintzU Beller

❮ Previous
Next ❯

Citations

Feb 27, 2019·Current Oncology Reports·Jessica GillenKathleen Moore
Jul 4, 2018·International Journal of Molecular Sciences·Ángela ÁyenHouria Boulaiz
Mar 27, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gregory D ConwayToni M Antalis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.