Combined heart-kidney transplantation: report on six cases

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
V J ColY Pirson

Abstract

Combined heart-kidney transplantation has become a new therapeutic solution for patients with coexisting, irreversible heart and kidney failure. Though this combined approach has several theoretical advantages over sequential transplantation, it has yet to be established that it does not jeopardize patient and graft outcomes. We here report our experience with six cases of combined heart-kidney transplantation from single donors and review the literature in order to clarify this issue. Four patients were kidney-transplant candidates with severe heart failure and two were heart-transplant candidates with independent chronic renal failure. Donors were selected on the basis of weight and size matching, ABO compatibility, and negative T-cell cross-match. The heart was always grafted first. The surgical procedure was uneventful in all cases. Heart and kidney function recovered quickly in all patients. Two patients died, one at day 45 from heart subacute rejection and the other one at day 157 from cerebral haemorrhage. The four remaining patients are alive 23-84 months after transplantation (2-year survival rate: 67%) and have well-functioning kidneys (creatinine clearance 31-83 ml/min) and hearts (left ventricular ejection fraction ...Continue Reading

Citations

May 13, 2003·Microsurgery·Minghui WangUwe Heemann
Oct 12, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E VermèsD Loisance
May 3, 2014·Cold Spring Harbor Perspectives in Medicine·Makoto TonshoJoren C Madsen
Apr 21, 2007·Transplantation Proceedings·L SepúlvedaF Alvarez
Apr 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J GillS Bunnapradist
Jan 19, 2008·Orvosi hetilap·Tamás BenkoZoltán Szabolcs
Apr 7, 1999·Current Opinion in Cardiology·J A Castillo-Lugo, K R Brinker
Mar 7, 2000·Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)·S D FritzscheR E Chinnock

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