PMID: 9179754May 1, 1997Paper

Combined hepatocellular carcinoma and cholangiocarcinoma in a mare

Journal of Comparative Pathology
M KatoK Kadota

Abstract

A hepatic malignant tumour composed of both hepatocellular and cholangiocellular elements was studied histologically, immunohistochemically and electron microscopically in an 18-year-old Thoroughbred mare. Bile canaliculi and alpha-fetoprotein were useful in identifying the hepatocellular element, and mucin and keratin were good markers of biliary differentiation. The simultaneous presence of bile canaliculi and mucin-producing cells in most of the neoplastic lesions suggested that this tumour arose from a stem cell with capacity to differentiate into hepatocytes and biliary epithelium.

References

Feb 1, 1969·The Journal of Pathology·L B Jeffcott
Jul 1, 1959·Cancer·P E STEINER, J HIGGINSON

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Citations

Aug 8, 2008·Veterinary Research Communications·M B ContiF Rueca
Dec 12, 2012·The Veterinary Quarterly·Susumu Ohfuji
Aug 14, 2010·Avian Pathology : Journal of the W.V.P.A·A J Van WettereH John Barnes
May 17, 2008·Avian Pathology : Journal of the W.V.P.A·I MikaelianD Martineau
Sep 3, 2008·Veterinary Clinical Pathology·Jenifer R GoldTracy Stokol
Aug 15, 1998·Equine Veterinary Journal·M KatoK Kadota
Mar 13, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Janet Beeler-MarfisiDorothee Bienzle
Dec 13, 2019·The Journal of Veterinary Medical Science·Hidetsugu HondaKoichi Kadota
Mar 4, 2008·The Veterinary Record·J L Habershon-ButcherG D Hallowell

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