Combined hepatocellular-cholangiocarcinoma: a population level analysis of incidence and mortality trends

World Journal of Surgical Oncology
Jiakun WangLinquan Wu

Abstract

The purpose of this study was to explore trends in incidence, incidence-based (IB) mortality, and survival for combined hepatocellular-cholangiocarcinoma (cHCC-CC) utilizing a population-based database to attract people's attention to this disease. The Surveillance, Epidemiology, and End Results (SEER) database was utilized to investigate the incidence and IB mortality for cHCC-CC from 2000 to 2014. Trends in age-adjusted incidence and IB mortality were characterized by the Joinpoint Regression program. The Kaplan-Meier method and log-rank test were utilized to implement survival analyses. Cox regression was utilized to estimate independent predictors of mortality. The incidence of cHCC-CC was 0.26 per 1,000,000 individuals in 2000 and 0.59 per 1,000,000 individuals in 2014, with an annual percent change (APC) (i.e., the extent of increase in incidence) of 3.84% (95% confidence interval [CI] 1.7-6.1; P < 0.05). The IB mortality also displayed a sustained increase (APC was 4.59%, 95% CI 1.9-7.4; P < 0.05). Compared to patients not undergoing surgery, patients undergoing surgical treatment experienced a significant increase in median survival (3 vs. 28 months; P < 0.001). However, the median survival decreased in patients with tu...Continue Reading

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Citations

Dec 6, 2020·World Journal of Surgical Oncology·Takamichi IshiiShinji Uemoto
Aug 6, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Dimitrios SchizasEvangelos Felekouras
Jun 21, 2021·Annals of Diagnostic Pathology·Thiyaphat LaohawetwanitSirawich Chaiparnich
Oct 10, 2021·Digestive Diseases and Sciences·Yoshihiro SakanoHidetoshi Eguchi
Jan 15, 2021·Case Reports in Gastroenterology·Sven H LoosenTom Luedde
Jan 4, 2022·Abdominal Radiology·Si Min ChiowHsien Min Low

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Methods Mentioned

BETA
biopsy

Software Mentioned

Joinpoint Regression
* Stat
SEER

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