Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis.

Annals of the Rheumatic Diseases
A L TanD McGonagle

Abstract

The pathogenesis of the early stages of hand osteoarthritis is poorly understood, but recent high-resolution magnetic resonance imaging (hrMRI) studies suggest that the joint ligaments have a major role in the phenotypic expression of the disease. To combine hrMRI and cadaveric histological studies to better understand the mechanisms of damage, and especially the role of joint ligaments and tendons in disease expression. hrMRI was carried out in the distal interphalangeal (DIP) and proximal interphalangeal (PIP) joints in 20 patients with osteoarthritis, with a disease duration < or = 12 months. Histological sections of the DIP and PIP joints were obtained from three dissecting-room specimens for comparative analysis. The collateral ligaments influenced the location of both hrMRI-determined bone oedema and bone erosion in early osteoarthritis. These changes were best understood in relation to the enthesis organ concept, whereby the interaction between ligament fibrocartilages leads to bone disease. Normal ligaments were commonly associated with microdamage at insertions corresponding to ligament thickening noted in early osteoarthritis. The ligaments also influenced the location of node formation in early osteoarthritis. The DI...Continue Reading

References

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Citations

Feb 2, 2013·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·A Robin Poole
Oct 20, 2010·Nature Reviews. Rheumatology·Dennis McGonagleAleksandra Radjenovic
Jan 21, 2009·Rheumatology·Dennis McGonagle, Ai Lyn Tan
Feb 7, 2007·Current Opinion in Rheumatology·Margreet Kloppenburg
Sep 16, 2006·Annals of the Rheumatic Diseases·K D BrandtL van de Putte
Feb 24, 2009·Arthritis Research & Therapy·David T Felson
Dec 21, 2013·Current Rheumatology Reports·Ida Kristin Haugen, Hilde Berner Hammer
Jun 14, 2013·Clinical Orthopaedics and Related Research·Nathalie MobarghaElisabet Hagert
Feb 15, 2013·The British Journal of Radiology·D A BinksA Radjenovic
Jan 15, 2013·Rheumatic Diseases Clinics of North America·Ali GuermaziFrank W Roemer
May 1, 2012·Seminars in Arthritis and Rheumatism·Li XuAli Guermazi
Jan 24, 2012·Best Practice & Research. Clinical Rheumatology·Zoe Ash, Dennis McGonagle
Oct 26, 2011·Bone·Sunita Suri, David A Walsh
Dec 8, 2010·The Journal of Hand Surgery·Robert A KaufmannRobert J Goitz
Nov 26, 2009·Rheumatic Diseases Clinics of North America·Helen I Keen, Philip G Conaghan
Jul 28, 2009·Radiologic Clinics of North America·Helen I Keen, Philip G Conaghan
Jun 2, 2009·Seminars in Arthritis and Rheumatism·Leonid Kalichman, Gabriela Hernández-Molina
Nov 7, 2008·Morphologie : Bulletin De L'Association Des Anatomistes·T Le CorrollerP Champsaur
Aug 19, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·D McGonagle
Jun 11, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiang DuGraeme M Bydder
Jan 15, 2010·Journal of Anatomy·Dennis McGonagleMichael Benjamin
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May 6, 2008·Clinical Radiology·M BenjaminG M Bydder
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Jul 28, 2009·Radiologic Clinics of North America·Antoine FeydyJean-Luc Drapé
Oct 31, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Dennis G McGonagleDouglas Veale
Nov 7, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Sibel Zehra AydinDennis McGonagle
Mar 2, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ya-Jun MaJiang Du
Jan 17, 2014·The Journal of Rheumatology·Margreet KloppenburgDésirée M van der Heijde

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