PMID: 7542824Aug 1, 1995Paper

Combined hormonal and radiation therapy for lymph node-positive prostate cancer

Urology
R WhittingtonA J Wein

Abstract

To evaluate the efficacy of combined radiation and hormonal therapy in patients with prostate cancer metastatic to the pelvic lymph nodes. Fifty consecutive patients with node-positive prostate cancer were evaluated by the Departments of Urology and Radiation Oncology at the University of Pennsylvania and offered combined hormonal and radiation therapy. All patients received pelvic radiation to 45 Gy, with a boost dose to the prostate to 65 to 71 gy. Forty-five of the patients were treated with concurrent hormonal therapy consisting of diethylstilbestrol (2 patients), orchiectomy (18 patients), leuprolide (5 patients), or combined androgen blockade (20 patients); the other 5 patients declined hormonal therapy. Patients represented a group with locally advanced disease with a high incidence of T3 tumors (66%), high grade (74%; Gleason score more than 7), high prostate-specific antigen (PSA) (40%; more than 30.0 ng/mL), and a high incidence of gross (36%) or bilateral (30%) adenopathy and a high incidence of multiply involved lymph nodes (62%). Median follow-up of patients is 42 months (range, 10 to 102). All 5 patients declining hormonal therapy relapsed within 18 months and only 1 patient survived longer than 3 years. Among pat...Continue Reading

References

Jun 1, 1979·International Journal of Radiation Oncology, Biology, Physics·N GreenL Skaist
Jan 1, 1979·International Journal of Radiation Oncology, Biology, Physics·G G Steel, M J Peckham
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·G E HanksJ B Owen
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·S A LeibelW F Whitmore

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Citations

Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Theodore J RobnettAlan J Wein
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·R WhittingtonA J Wein
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·G E HanksM V Pilepich
Dec 16, 1998·The American Journal of Surgical Pathology·L ChengD G Bostwick
Apr 29, 1998·Seminars in Radiation Oncology·A Pollack, G K Zagars

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