Combined hormonal contraception and bone health: a systematic review

Contraception
Summer L MartinsAnna F Glasier

Abstract

This systematic review examined whether women who use combined hormonal contraception experience changes in risk of fracture or bone mineral density (BMD) that differ from nonusers. We identified 86 articles from PubMed and EMBASE (published 1966 to August 2005) that reported on fracture or BMD outcomes by use of combined hormonal contraceptives. The evidence relating to combined oral contraceptives (COCs) and fracture is inconclusive, as results from the available studies conflict. Studies of adolescent and young adult women generally found lower BMD among COC users than nonusers. Evidence for premenopausal adult women suggested no differences in BMD between COC users and nonusers. COC use in perimenopausal and postmenopausal women preserved bone mass, while nonusers lost BMD, but BMD among former COC users in this age group was the same as for never-users. Evidence for other combined hormonal methods was very limited, with one study indicating no effect of combined hormonal injectable use among premenopausal women on BMD and one study suggesting lower BMD among premenopausal users of the NuvaRing than in nonusers.

References

Feb 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M A HansenC Christiansen
Apr 1, 1991·Calcified Tissue International·K LaitinenP Keto
Apr 1, 1990·The British Journal of Radiology·M L HallP J Ell
Feb 1, 1989·American Journal of Obstetrics and Gynecology·T LloydD R Halbert
Aug 1, 1988·American Journal of Obstetrics and Gynecology·M M HreshchyshynM Anbar
Jul 1, 1984·Calcified Tissue International·O Johnell, B E Nilsson
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H MallminR Bergström
Mar 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M TuppurainenE Alhava
Mar 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W HaenggiP Jaeger
May 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M A Hansen
Jan 1, 1993·American Journal of Public Health·D Kritz-Silverstein, E Barrett-Connor
Mar 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L J MeltonB L Riggs
Feb 1, 1993·European Journal of Clinical Investigation·S MurphyJ E Compston
Jun 1, 1996·Journal of Epidemiology and Community Health·T W O'NeillA J Silman
Jun 1, 1997·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·A VolpeC Battaglia
Sep 24, 1998·Calcified Tissue International·P MasarykJ Reeve
Apr 30, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·B A Cromer
May 8, 1999·Lancet·K MichaëlssonS Ljunghall
Aug 10, 1999·Lancet·C La VecchiaS Gallus
Sep 12, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M GambaccianiA R Genazzani
Feb 15, 2001·American Journal of Obstetrics and Gynecology·A TavaniS Franceschi
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·S M OttW E Barlow
Jun 21, 2001·American Journal of Epidemiology·K MichaëlssonS Ljunghall
Oct 19, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M J GraingeD J Hosking
Jun 18, 2002·Maturitas·UNKNOWN Progetto Menopausa Italia Study Group
Aug 2, 2002·Journal of Women's Health & Gender-based Medicine·Lorraine Silver Wallace, Joyce E Ballard
Aug 28, 2002·American Journal of Epidemiology·Gillian A HawkerArnulf Langhammer
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonB Lawrence Riggs
Jun 27, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M C LauL J Melton
Oct 17, 2003·Contraception·Susan D ReedSusan M Ott
Mar 11, 2004·Journal of Pediatric and Adolescent Gynecology·Eduardo Lara-TorreS Paige Hertweck
May 4, 2004·Obstetrics and Gynecology·Abbey B BerensonAngelyn Thomas
Jun 12, 2004·The Journal of Pediatrics·Tom LloydThomas J Beck

❮ Previous
Next ❯

Citations

Mar 14, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M L RobinsonD Dolny
Dec 13, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M ModleskyG A Dudley
Mar 3, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S WeiA Venn
May 12, 2011·Reviews in Endocrine & Metabolic Disorders·Michelle M Isley, Andrew M Kaunitz
Nov 26, 2010·Current Osteoporosis Reports·Shuying WeiGraeme Jones
Jun 6, 2009·Current Opinion in Obstetrics & Gynecology·Lama L Tolaymat, Andrew M Kaunitz
Nov 6, 2007·Clinical Obstetrics and Gynecology·Nathalie KappLynn Borgatta
Jul 16, 2008·Current Opinion in Pediatrics·Sarah A B Pitts, S J Emans
Apr 9, 2008·The Journal of Clinical Endocrinology and Metabolism·Susan M Ott
Mar 6, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Rebecca H AllenAndrew M Kaunitz
Dec 6, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jos H H Thijssen
Jul 5, 2012·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Lina WarholmPernille Ravn
Jan 13, 2016·Menopause : the Journal of the North American Menopause Society·Delia ScholesSusan M Ott
Apr 16, 2013·Current Problems in Pediatric and Adolescent Health Care·Alvina R Kansra, Seema Menon
Nov 20, 2012·Journal of Pediatric and Adolescent Gynecology·Kelly L Kantartzis, Gina S Sucato
Aug 21, 2012·Nursing for Women's Health·Luz S Porter, Nola A Holness
Sep 17, 2011·Contraception·Johannes Bitzer, James A Simon
Dec 17, 2009·Contraception·Delia ScholesSusan M Ott
Jan 28, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·Rebecca S French, Frances M Cowan
Nov 9, 2011·Journal of Midwifery & Women's Health·Joyce King
Sep 11, 2009·Clinical Endocrinology·Markus Herrmann, Markus J Seibel
May 21, 2015·BMC Endocrine Disorders·Talita Poli BiasonHélio Rubens de Carvalho Nunes
Jul 6, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Sarah M R Hardman, Ailsa E Gebbie
Jul 17, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Monica V Dragoman
Jun 22, 2012·Contraception·Carmine NappiCostantino Di Carlo
Jul 22, 2015·The Cochrane Database of Systematic Reviews·Laureen M LopezFrans M Helmerhorst
Jun 25, 2014·The Cochrane Database of Systematic Reviews·Laureen M LopezMario Chen
Nov 19, 2020·Environmental Health Perspectives·Kristen UpsonDonna D Baird
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology
Dec 16, 2021·Minerva Obstetrics and Gynecology·Morena L RoccaCostantino DI Carlo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.