PMID: 11902819Mar 21, 2002Paper

Combined hormone replacement therapy improves endothelial function in healthy postmenopausal women

Journal of Internal Medicine
B Guzic-SalobirL Vrabic

Abstract

Large scale epidemiological studies suggest that hormone replacement therapy (HRT) reduces cardiovascular events in postmenopausal women. Improvement in endothelial function may contribute to this protective effect. In a prospective, double blind study, 61 healthy postmenopausal women were randomized to receive either oral continuous combined HRT [oestradiol 2 mg and norethisterone acetate (NETA) 1 mg per day] or placebo. Endothelial function, assessed by flow-mediated vasodilation (FMD) of the brachial artery and expression of soluble endothelial cell adhesion molecules (CAM) were determined before, after 3 and 6 months of therapy. The FMD was significantly improved in women on combined HRT (from 5.97% to 10.94% after 3 months and to 10.58% after 6 months; both P < 0.01 versus baseline values) and did not change in the placebo group (6.92% at baseline, 5.86% after 3 and 6.26% after 6 months). After 3 months of combined HRT, significant decreases of 24.6% for E-selectin and 13.9% for intercellular adhesion molecule-1 (ICAM-1) were observed (both P < 0.01 versus baseline values) and were sustained after 6 months of therapy, whilst no differences emerged in the placebo group. Oestradiol and norethisterone acetate improve endothel...Continue Reading

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Citations

Jun 4, 2008·Menopause : the Journal of the North American Menopause Society·Joseph YeboahDavid M Herrington
Dec 17, 2011·Women's Health·Kate Maclaran, John C Stevenson
Jun 24, 2004·Journal of General Internal Medicine·Shelley R SalpeterEdwin E Salpeter
Mar 15, 2011·The American Journal of Medicine·S Mitchell HarmanDennis M Black
Jan 28, 2009·Brain, Behavior, and Immunity·Elliot M FriedmanCarol D Ryff
Jul 19, 2005·Annals of the New York Academy of Sciences·S Mitchell HarmanDebra R Judelson
Oct 19, 2004·Atherosclerosis·André Arpad FaludiJose Eduardo M R Sousa
May 3, 2003·The American Journal of Medicine·Francesco SquadritoGiovanni Squadrito
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Jun 26, 2003·Journal of Internal Medicine·E J J DuschekC Netelenbos
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Sep 22, 2019·Medicina·Angelo Cagnacci, Martina Venier
Apr 21, 2017·Clinical Science·Christine Maric-Bilkan

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