PMID: 11337155May 5, 2001Paper

Combined hydroxypropyl-beta-cyclodextrin and poly(alkylcyanoacrylate) nanoparticles intended for oral administration of saquinavir

International Journal of Pharmaceutics
H BoudadG Ponchel

Abstract

The aim of this study was to prepare and characterize an hydroxypropyl-beta-cyclodextrin-saquinavir inclusion complex with the purpose of incorporating this complex into poly(alkylcyanoacrylate) nanoparticles in order to increase the drug loading. Hydroxypropyl-beta-cyclodextrin-saquinavir complex was characterized by thermal (differential scanning calorimetry), crystallographic (X-ray diffractography) and spectroscopic methods (circular dichroism, H1-NMR). Nanoparticles were prepared by polymerization of alkylcyanoacrylate monomers (isobutyl- and isohexylcyanoacrylate) in a water solution of the complex and further characterized. The apparent solubility of saquinavir was increased 400-fold at pH 7.0 in presence of hydroxypropyl-beta-cyclodextrin owing to the formation of a drug-cyclodextrin complex as demonstrated mainly by 1H NMR and confirmed by other techniques. Saquinavir-loaded nanoparticles could be easily prepared in the presence of a drug-cyclodextrin complex. It was found that large amounts of cyclodextrins remained associated with the particles, resulting in a 20-fold increase in saquinavir loading compared to nanoparticles prepared in the absence of cyclodextrins. This study has shown that the loading in saquinavir ...Continue Reading

References

Jul 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·J Kreuter
Jul 1, 1996·The Journal of the Association of Nurses in AIDS Care : JANAC·D J Porche
Oct 1, 1996·Journal of Pharmaceutical Sciences·T Loftsson, M E Brewster
Jan 1, 1997·Critical Reviews in Therapeutic Drug Carrier Systems·D O Thompson
Nov 21, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·R M HoetelmansJ H Beijnen
Oct 1, 1998·Antiviral Research·A MollaD J Kempf
Mar 8, 2000·International Journal of Pharmaceutics·D C BibbyI G Tucker
Jun 6, 2000·Advanced Drug Delivery Reviews·D DuchêneD Wouessidjewe
Jun 6, 2000·Advanced Drug Delivery Reviews·F Hirayama, K Uekama
Jun 6, 2000·Advanced Drug Delivery Reviews·G C Williams, P J Sinko
Feb 19, 2002·Chemical Reviews·Kaneto UekamaTetsumi Irie

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Citations

Sep 14, 2006·Pharmaceutical Research·Lipa K Shah, Mansoor M Amiji
Apr 23, 2003·Advanced Drug Delivery Reviews·Christine VauthierPatrick Couvreur
Oct 11, 2003·Biotechnology Advances·Mamata SinghU C Banerjee
Nov 30, 2011·Journal of Nanobiotechnology·Anil Mahapatro, Dinesh K Singh
Dec 16, 2005·AAPS PharmSciTech·Rajeswari ChallaR K Khar
Dec 18, 2013·International Journal of Pharmaceutics·Nadiah ZafarAbdelhamid Elaissari
Jul 2, 2014·Nanomedicine·Jaya Raju Lakkakula, Rui Werner Maçedo Krause
May 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alejandro SosnikAngel M Carcaboso
Apr 6, 2011·Expert Opinion on Drug Delivery·Maite AgüerosJuan M Irache
May 27, 2015·Nanomedicine·Julieta C Imperiale, Alejandro D Sosnik
Sep 5, 2012·Carbohydrate Polymers·Liandong HuQiaofeng Hu
Aug 27, 2009·Expert Opinion on Drug Delivery·Erem Bilensoy, A Atilla Hincal
Nov 29, 2007·Journal of Drug Targeting·Christine VauthierGilles Ponchel
Oct 27, 2007·Colloids and Surfaces. B, Biointerfaces·José L AriasAngel V Delgado
May 7, 2008·Nanotechnology·A TrapaniM J Alonso
Aug 19, 2007·Chemical Communications : Chem Comm·Larisa G KlapshinaSergey B Bushuk
Jul 23, 2019·Expert Opinion on Drug Delivery·Yuqing GongSantosh Kumar
Apr 4, 2021·Pharmaceutics·Susana Santos BragaFilipe A Almeida Paz
Nov 20, 2016·International Journal of Pharmaceutics·Dominique Duchêne, Amélie Bochot
Mar 14, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Angela LopedotaGiuseppe Trapani

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