Combined hypofractionated radiation and hormone therapy for the treatment of intermediate-risk prostate cancer

International Journal of Radiation Oncology, Biology, Physics
Michael YassaJean-Paul Bahary

Abstract

Because of the low alpha/beta value of prostate cancer, a therapeutic gain may be possible with a hypofractionated radiation scheme, and this gain may be further increased with the adjunct of hormone therapy. A Phase II study was undertaken to study the toxicity of such a treatment. Forty-two patients with intermediate-risk prostate cancer were recruited for this study. Neoadjuvant and concomitant hormone therapy consisted of one injection of leuprolide acetate (4-month preparation) and 1 month of oral nonsteroidal, anti-androgen medication starting on the day of the injection. Radiation treatment was started 8 weeks after the injection and patients received 57 Gy in 19 fractions. Median follow-up was 46 months. The treatment was well tolerated and no interruptions occurred. The majority (59%) had Grade 0 or 1 acute genitourinary (GU) toxicity, whereas 36% had Grade 2 and 5% had Grade 3 acute GU toxicity. Only Grade 1 or 2 gastrointestinal toxicity was seen. All chronic toxicity was of Grade 1 or 2 except for 3 patients (8%) with Grade 3 toxicity. Sixty-eight percent (68%) of patients had no long-term side effects from the treatment. At time of analysis, 79% showed no sign of treatment failure. Hypofractionated radiation with n...Continue Reading

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Citations

Jul 4, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Víctor Macías, Albert Biete
Aug 27, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S SupiotA Lisbona
Nov 6, 2009·Radiation Oncology·Jarad M MartinCharles N Catton
Feb 18, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·A C TreeM Partridge
Jun 9, 2012·International Journal of Radiation Oncology, Biology, Physics·Valérie FonteyneGert De Meerleer
Jun 23, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael BaumannJim Denham
Mar 11, 2015·International Journal of Radiation Oncology, Biology, Physics·Olivier ChapetDavid Azria
Apr 4, 2015·International Journal of Radiation Oncology, Biology, Physics·Stefania ClementeValeria Landoni
Aug 1, 2012·Expert Review of Anticancer Therapy·Peter VavassisMichael Yassa

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