Combined Immunoscore of CD103 and CD3 Identifies Long-Term Survivors in High-Grade Serous Ovarian Cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Hans-Christian BösmüllerAnnette Staebler

Abstract

Increased numbers of tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSC) are associated with improved clinical outcome. Intraepithelial localization of TILs might be regulated by specific homing receptors, such as CD103, which is widely expressed by intraepithelial lymphocytes. Given the emerging role of CD103 TILs, we aimed to assess their contribution to the prognostic value of immunoscoring in HGSC. The density of intratumoral CD3 and CD103 lymphocytes was examined by immunohistochemistry on a tissue microarray of a series of 135 patients with advanced HGSC and correlated with CD4, CD8, CD56, FoxP3, and TCRγ T-cell counts, as well as E-cadherin staining and conventional prognostic parameters and clinical outcome. Both the presence of CD103 cells, as well as high numbers of intraepithelial CD3 lymphocytes (CD3E), showed a significant correlation with overall survival, in the complete series, as well as in patients with optimal debulking and/or platinum sensitivity. Combining CD3 and CD103 counts improved prognostication and identified 3 major subgroups with respect to overall survival. The most pronounced effect was demonstrated for patients with optimally resected and platinum-sensitive tumors. P...Continue Reading

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Citations

Jun 21, 2016·Journal de gynécologie, obstétrique et biologie de la reproduction·M NayamaD Vinatier
Dec 17, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hans-Christian BösmüllerAnnette Staebler
Jan 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Briana G Nixon, Ming O Li
Jun 1, 2020·Journal for Immunotherapy of Cancer·John P LynesEdjah K Nduom
Aug 29, 2019·Frontiers in Immunology·Sarah NersesianJeanette E Boudreau
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Jul 8, 2020·Cancers·Alejandra MartinezChristel Devaud
Jun 17, 2020·The International Journal of Biological Markers·Xingxia ZhangKa Li
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Sep 28, 2018·Frontiers in Immunology·Nina DumauthiozPedro Romero
Aug 15, 2018·Cancers·Nkechiyere G NwaniDaniela Matei
Jun 20, 2020·Journal of Leukocyte Biology·Sohini RoyDouglas B Johnson
Jun 9, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhi-Qiang WangPeter H Watson
Jul 1, 2019·Trends in Immunology·Simone L ParkLaura K Mackay
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Mar 24, 2021·The Journal of Experimental Medicine·Karolina OkłaWeiping Zou
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Aug 3, 2021·Frontiers in Immunology·Eric de SousaMarkus Maeurer
Mar 24, 2021·Cold Spring Harbor Perspectives in Biology·Simone L Park, Laura K Mackay

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