Combined impact of risk factors on the subsequent development of hypertension

Journal of Hypertension
Yuli HuangDingli Xu

Abstract

This study aimed to develop a cumulative score composed of seven risk factors: age, resting heart rate, overweight or obesity, dyslipidemia, hyperuricemia, impaired glucose regulation, and impaired estimated glomerular filtration rate (eGFR), to evaluate the risk of new-onset hypertension. We retrospectively conducted a cohort study in 23 665 participants free from hypertension at baseline, who attended at least two annual health examinations between 2011 and 2016. We defined hypertension as SBP of 140 mmHg or less and/or DBP of at least 90 mmHg, according to the 2010 Chinese guidelines for the management of hypertension. We computed a composite, individual-level cumulative score incorporating all seven risk factors (no = 0 point; yes = 1 point; total range 0-7 points). Cox regression was used to analyze the association between cumulative score and risk of hypertension. A total of 2305 participants developed hypertension during a median follow-up period of 3.6 years. Compared with participants with 0 points, the adjusted hazard ratios (95% confidence intervals) for the development of hypertension for those with 2, 3, and at least 4 points were 1.61 (1.29-2.02), 2.05 (1.64-2.57) and 2.77 (2.22-3.46), respectively (P trend < 0.00...Continue Reading

References

Dec 18, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masahiko TozawaShuichi Takishita
Dec 14, 2005·Hypertension·Ruben O HalperinJ Michael Gaziano
Dec 28, 2006·Hypertension·Eswar KrishnanLewis Kuller
Oct 30, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Taku InoueShuichi Takishita
Mar 1, 2008·European Heart Journal·David E LaaksonenJukka T Salonen
Feb 6, 2009·BMJ : British Medical Journal·Judith HsiaUNKNOWN Women's Health Initiative Research Group
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Dec 30, 2009·Hypertension·Laura PaulSandosh Padmanabhan
Apr 10, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Genjiro KimuraMichio Fukuda
Jun 22, 2012·European Journal of Preventive Cardiology·Mark WoodwardUNKNOWN from the Asia Pacific Cohort Studies Collaboration
Sep 21, 2013·Journal of Hypertension·Mohammad TalaeiNizal Sarrafzadegan
Dec 3, 2013·Mayo Clinic Proceedings·Arpit SaxenaSteven N Blair
Jun 1, 2014·Journal of Hypertension·Anxin WangShouling Wu
Nov 20, 2016·International Journal of Cardiology·Yichong LiLinhong Wang

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Citations

Nov 19, 2019·International Journal of Hypertension·Xinyi Wu, Zhonghua Wang
May 28, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chunpeng JiWei Cui
Dec 4, 2019·Journal of Hypertension·Cesare CuspidiGiuseppe Mancia

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