Combined inhibition of neutral endopeptidase with angiotensin converting enzyme or endothelin converting enzyme in experimental diabetes

Journal of Hypertension
Ilkka TikkanenMark E Cooper

Abstract

The effects of combined inhibition of neutral endopeptidase (NEP) with either angiotensin-converting enzyme (ACE), or endothelin-converting enzyme (ECE) on blood pressure, urinary albumin excretion and heart weight were explored in experimental diabetes. Streptozotocin-induced diabetic Sprague-Dawley rats were treated with vehicle, the NEP/ACE inhibitor S 21402, the NEP/ECE inhibitor CGS 26303, the NEP inhibitor SCH 42495, the ACE inhibitor captopril or the endothelin receptor antagonist bosentan for 4 weeks. Blood pressure was measured by tail-cuff method and radiotelemetry. Albuminuria, plasma renin activity and plasma atrial natriuretic peptide (ANP) were determined by radioimmunoassay. NEP binding was assessed by in vitro quantitative autoradiography. Metabolic and biochemistry parameters including food intake, 24-h urine volume, plasma glucose, glycated hemoglobin, glomerular filtration rate (GFR) and urinary sodium excretion were also determined. Mean blood pressure over the 4-week study period after commencement of treatment was reduced to a similar extent by a range of treatments including the ACE inhibitor, NEP/ACE inhibitor, endothelin receptor antagonist, NEP/ECE inhibitor, but not the NEP inhibitor, compared with ve...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M C Fournié-ZaluskiB P Roques
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·B P BrockwayS H Azar
Feb 1, 1973·Journal of Applied Physiology·R D Buñag
May 1, 1971·Australian and New Zealand Journal of Medicine·W R Adam, J K Dawborn
Jul 1, 1995·Journal of Cardiovascular Pharmacology·J F FrenchR C Dage
Oct 14, 1994·Biochemical and Biophysical Research Communications·S De LombaertR L Webb
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·M C Fournié-ZaluskiJ B Michel
Jan 26, 1996·Biochemical Pharmacology·A J Turner, L J Murphy
Dec 1, 1996·Kidney International·T J RabelinkH A Koomans
Nov 1, 1996·Journal of Cardiovascular Pharmacology·A A SeymourC R Dorso
Jul 1, 1997·Journal of the American Society of Nephrology : JASN·D M Pollock, J S Polakowski
Apr 16, 1998·Scandinavian Cardiovascular Journal. Supplement·C I JohnstonL M Burrell
Oct 30, 1998·Journal of Hypertension·W G Haynes, D J Webb
Jun 24, 2000·JAMA : the Journal of the American Medical Association·M E Cooper, C I Johnston
Oct 21, 2000·American Journal of Hypertension·L M BurrellC I Johnston
Dec 1, 1961·Klinische Wochenschrift·F H SCHMIDT

❮ Previous
Next ❯

Citations

Mar 2, 2012·American Journal of Physiology. Renal Physiology·Liliya M YamaleyevaMark C Chappell
Aug 5, 2015·Journal of Clinical Medicine·Lidia AnguianoMaría José Soler
Apr 19, 2005·Expert Opinion on Investigational Drugs·Kei FukamiJosephine M Forbes
May 18, 2004·Journal of Clinical Pharmacology·Marc PfisterJeffrey S Barrett
Mar 15, 2015·Circulation Research·Suzanne Oparil, Roland E Schmieder
Feb 7, 2020·Physiological Reports·Laale F AlawiKhalid M Elased
Apr 2, 2014·BioMed Research International·Franca Maria TuccilloGiuseppe Scala
Sep 12, 2019·Current Hypertension Reports·Omar AzzamMarkus P Schlaich
Jul 15, 2009·Experimental Biology and Medicine·Victoriya A RufanovaNataliya A Medvedeva
Jul 24, 2003·American Journal of Physiology. Renal Physiology·Kumar SharmaGyorgy Hajnoczky
Nov 3, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Speranza Rubattu, Giovanna Gallo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.