PMID: 8970554Dec 1, 1996Paper

Combined insulin-like growth factor-1 and growth hormone improves weight loss and wound healing in burned rats

The Journal of Trauma
N A MeyerD N Herndon

Abstract

The anabolic effects of growth hormone (GH) in burned patients appear to act both directly and through insulin-like growth factor-1 (IGF-1). We, therefore, hypothesize that exogenous GH plus IGF-1 will attenuate increases in metabolism and lean muscle wasting while promoting wound healing. Rats, each weighing 440-470 g, were given a 35% total body surface area, full-thickness scald burn and divided into four groups to receive placebo (burned controls), bovine GH (2.5 mg/kg/day), IGF-1 (2.0 mg/kg/day), or bovine GH plus rhIGF-1 (2.5 + 2.0 mg/kg/day), respectively, for 8 weeks. Total body weight gain after 8 weeks averaged 110 g for GH plus IGF-1 compared with gains of 49 and 11 g for GH or IGF-1 alone, respectively. Burned controls lost 24 g. Metabolic rates were significantly reduced in all groups receiving growth hormones. Gastrocnemius muscle dry weight was significantly increased in those receiving GH plus IGF-1 compared with GH and IGF-1 alone or burned controls (p < .01). Data show that GH plus IGF-1 synergistically increased lean muscle weight, total body weight, and was more effective in re-epithelialization of the burn wound than either GH or IGF-1 alone.

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Citations

Dec 5, 2002·Burns : Journal of the International Society for Burn Injuries·Mahmut BasogluS Selcuk Atamanalp
Jan 23, 1999·Burns : Journal of the International Society for Burn Injuries·K P SinghR J Dash
Nov 9, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·V Dunaiski, D A Belford
Oct 29, 2013·Journal of Translational Medicine·Lucia Guerra-MenéndezInma Castilla-Cortázar
Apr 15, 2008·Burns : Journal of the International Society for Burn Injuries·Zafer DokumcuAhmet Celik
Dec 18, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Aya Umeda-IkawaKunio Doi
Sep 20, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Itoro E ElijahDavid N Herndon
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·P V Carroll
Sep 22, 1998·Anesthesiology·N MacLennanB F Cullen
Jun 1, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Yee M WongMatthias Majetschak
Aug 9, 2003·Critical Care Medicine·Jason ShipmanNaji N Abumrad
Jul 24, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·P Geoff VanaMatthias Majetschak
Feb 27, 2018·Tissue Engineering. Part a·Mark L WangAndrzej Fertala
Aug 24, 1999·Gene Therapy·M G JeschkeD N Herndon
Feb 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ambikaipakan BalasubramaniamJ Howard James
Jan 16, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruxandra Draghia-AkliJeffrey L Nordstrom
Dec 13, 2003·Endocrine Reviews·Stephanie R EdmondsonChristopher J Wraight
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·R A Frost, C H Lang
Mar 4, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·M G JeschkeD N Herndon
Jun 14, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohan R K DasuJ Regino Perez-Polo
Jul 10, 2018·Advanced Drug Delivery Reviews·Patricia RousselleGuila Dayan
Nov 15, 2012·Journal of Translational Medicine·Juan E Puche, Inma Castilla-Cortázar

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