Combined intensity-modulated radiation therapy and brachytherapy in the treatment of cervical cancer

International Journal of Radiation Oncology, Biology, Physics
Dusten M MacdonaldPerry W Grigsby

Abstract

This treatment planning study compared pseudo-step-wedge intensity modulation (PSWIM), intensity-modulated radiation therapy (IMRT), and conventional external irradiation, all combined with brachytherapy, for treatment of patients with cervical cancer. This was a prospective study of 10 patients treated with PSWIM delivering 50.4 Gy to the pelvic lymph nodes and 20 Gy to the cervical tumor. This treatment was compared with a conventional treatment plan with a four-field box to 45 Gy and to an IMRT plan delivering 45 Gy. In each case, brachytherapy was prescribed to a total Point A low-dose-rate equivalent dose of 85 Gy. Total doses to Points A, Point P, the bladder point, and the rectal point were calculated. Acute toxicity and treatment response were prospectively recorded. The mean PSWIM total low-dose-rate equivalent dose to Points A and P (97.3 Gy and 65.1 Gy, respectively) was significantly higher, the mean rectal dose was the same, and the mean bladder dose was higher than with IMRT or four-field box. No acute toxicity of greater Grade 2, as defined by the than Radiation Therapy Oncology Group, was experienced. The positron emission tomography-based treatment response compared favorably with our institutional experience. ...Continue Reading

References

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Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Subir NagUNKNOWN Image-Guided Brachytherapy Working Group
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Nov 22, 2007·JAMA : the Journal of the American Medical Association·Julie K SchwarzPerry W Grigsby

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Citations

Jun 26, 2009·Current Opinion in Oncology·Perry W Grigsby
Mar 29, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yevgeniya Jane Mikhailovna IoffePremal H Thaker
Dec 3, 2014·PET Clinics·Christina K SpeirsJeffrey D Bradley
Sep 2, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R MazeronC Haie-Méder
Apr 24, 2018·Nuclear Medicine Communications·Shanmuga S PalaniswamyPadma Subramanyam
Feb 18, 2010·Expert Review of Pharmacoeconomics & Outcomes Research·Elfriede Greimel, Andrew John Nordin

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