[Combined intravenous administration of diclofenac and apazone for postoperative analgesia A randomized study of 112 patients with access to i. v. on-demand analgesia after minor orthopaedic operations.].

Der Schmerz
P SteffenW Seeling

Abstract

In a double-blind, randomized, placebo-controlled study, 112 patients scheduled for knee-joint arthrotomies or minor orthopaedic operations received 75 mg diclofenac, 600 mg apazone, the combination of 75 mg diclofenac and 600 mg apazone, or placebo (50 ml NaCl 0.9%) as a single i.v. dose immediately after operation. Postoperative pain intensity was measured by a numeric rating scale. All patients were allowed to self-administer piritramide from a PCA (patient-controlled analgesia) pump (Prominjekt, Pharmacia, Sweden) in 2-mg boluses every 5 min during the first 6 h and subsequently every 15 minfor another 18 h after surgery. The patients receiving diclofenac, apazone, or the combination of diclofenac and apazone required a significantly lower cumulated dose of piritramide during the first 24 h after operation than did placebo-treated subjects (38 mg vs 39 mg vs 27 mg vs 67 mg;P<0.05), but there were no significant differences among the former three groups of patients. The incidence of typical side effects of opioids and antipyretic anti-inflammatory analgesics (nausea, vomiting, stomach ache, headache, vertigo) was low, and they were easily controlled in all cases. Postoperative combined application of the nonsteroidal anti-in...Continue Reading

References

Feb 1, 1977·The Journal of Pharmacy and Pharmacology·D A LewisJ Bird
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Dec 1, 1971·The Journal of Pharmacy and Pharmacology·D A LewisR J Ancill
Jun 1, 1993·The British Journal of Oral & Maxillofacial Surgery·G M WaltonD Rickwood

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Citations

Aug 29, 2018·The Cochrane Database of Systematic Reviews·Ewan D McNicolRoman Schumann
Jul 7, 2005·Langenbeck's Archives of Surgery·Laureano Fernández-CruzSalvador Navarro

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