Combined line-cross and half-sib QTL analysis in Duroc-Pietrain population.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Guisheng LiuK Schellander

Abstract

A Duroc-Pietrain resource population was built to detect quantitative trait loci (QTL) that affect growth, carcass composition, and pork quality. The data were analyzed by applying three least-squares Mendelian models: a line-cross (LC) model, a half-sib (HS) model, and a combined LC and HS model (CB), which enabled the detection of QTL that had fixed, equal, and different allele frequencies for alternate breed alleles, respectively. Permutation tests were performed to determine 5% chromosome-wide and 5% genome-wide threshold values. A total of 40 (137) QTL were detected at the 5% genome-wide (chromosome-wide) level for the 35 traits analyzed. Of the 137 QTL detected, 62 were classified as the LC type (LC-QTL), 47 as the HS type (HS-QTL), and 28 as the CB type (CB-QTL). The results indicate that implementation of a series of model-based framework is not only beneficial to detect QTL, but also provides us with a new and more robust interpretation from which further methodology could be developed.

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Citations

Jun 23, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Muhammad Jasim UddinKarl Schellander
Sep 13, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hanna HeidtChristine Große-Brinkhaus
Oct 28, 2010·Genetics, Selection, Evolution : GSE·Christine Grosse-BrinkhausErnst Tholen
Jul 7, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Stefan KärstGudrun A Brockmann
Jan 5, 2011·International Journal of Immunogenetics·M J UddinK Schellander
Nov 4, 2016·Asian-Australasian Journal of Animal Sciences·Qingli MengMeiying Fang
Sep 3, 2016·International Journal of Molecular Sciences·Julia WelzenbachChristine Große-Brinkhaus
Oct 24, 2017·Asian-Australasian Journal of Animal Sciences·Jianping QuanJie Yang

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