Combined liver-kidney transplantation versus liver transplant alone based on KDIGO stratification of estimated glomerular filtration rate: data from the United Kingdom Transplant registry - a retrospective cohort study

Transplant International : Official Journal of the European Society for Organ Transplantation
Francesca TintiM Thamara P R Perera

Abstract

Patient selection for combined liver-kidney transplantation (CLKT) is a current issue on the background of organ shortage. This study aimed to compare outcomes and post-transplant renal function for patients receiving CLKT and liver transplantation alone (LTA) based on native renal function using estimated glomerular filtration rate (eGFR) stratification. Using the UK National transplant database (NHSBT) 6035 patients receiving a LTA (N = 5912; 98%) or CLKT (N = 123; 2%) [2001-2013] were analysed, and stratified by KDIGO stages of eGFR at transplant (eGFR group-strata). There was no difference in patient/graft survival between LTA and CLKT in eGFR group-strata (P > 0.05). Of 377 patients undergoing renal replacement therapy (RRT) at time of transplantation, 305 (81%) and 72 (19%) patients received LTA and CLKT respectively. A significantly greater proportion of CLKT patients had severe end-stage renal disease (eGFR < 30 ml/min/1.73 m2 ) at 1 year post-transplant compared to LTA (9.5% vs. 5.7%, P = 0.001). Patient and graft survival benefit for patients on RRT at transplantation was favouring CLKT versus LTA (P = 0.038 and P = 0.018, respectively) but the renal function of the long-term survivors was not superior following CLKT....Continue Reading

References

May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Satheesh NairPaul J Thuluvath
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Caroline CreputBernard Charpentier
Sep 5, 2003·The New England Journal of Medicine·Akinlolu O OjoRobert M Merion
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gülçin DemirciBjoern Nashan
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas A GonwaGoran B Klintmalm
Aug 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mical S CampbellK Rajender Reddy
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S FengR M Merion
Aug 23, 2006·Archives of Surgery·Richard RuizRonald W Busuttil
Aug 31, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T A GonwaN Ahsan
May 6, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Timothy M SchmittPatrick G Northup
Mar 25, 2010·Clinical Transplantation·Martin S ZandAdel Bozorgzadeh
Sep 4, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Titte R SrinivasJesse D Schold
Oct 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J R CassutoP Abt
Apr 3, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eric F MartinKia Saeian
Jun 12, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T HibiG W Burke
Jul 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M K NadimY S Genyk
Jul 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R RuebnerP P Reese
Jul 25, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M K NadimY S Genyk
Dec 15, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Cristin CoquillardRoberto Gedaly
Nov 30, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Georg Heinze, Daniela Dunkler
Apr 14, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver

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Citations

Apr 25, 2019·Journal of Clinical Immunology·Maylene XieAndrej A Petrov
Oct 4, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Rafat HoroubSeyed Ali Malek-Hosseini
Apr 10, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Robert C MinneeHerold J Metselaar
Jul 25, 2021·Cancers·Fabrizio FabriziEzequiel Ridruejo

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