Combined Low Densities of FoxP3+ and CD3+ Tumor-Infiltrating Lymphocytes Identify Stage II Colorectal Cancer at High Risk of Progression

Cancer Immunology Research
Tommaso CavalleriAlleanza contro il Cancro (ACC) Colorectal Cancer Working Group

Abstract

The densities of CD3+ and CD8+ tumor-infiltrating lymphocytes (TILs), combined with tumor-node-metastasis (TNM) staging, have prognostic value for patients with nonmetastatic colorectal cancer. We compared the prognostic value of CD3+ and FoxP3+ TILs at the invasive front, TNM classifiers, and microsatellite (MS) status in a trial set of patients with stage II and III colorectal cancer (n = 413), by recursive partitioning with a classification and regression tree (CART). Significant prognostic factors and interactions were reassessed by logistic regression and Cox proportional-hazards modeling in the trial and a validation set (n = 215) of patients with stage II colorectal cancer. In the trial set, CART indicated that TIL numbers were of value only in predicting recurrence risk for stage II cancers, where low densities of FoxP3+ TILs ranked first and low densities of CD3+ TILs further stratifying risk. Multivariate analysis showed that TILs interacted with tumor stage (FoxP3+, P = 0.06; CD3+, P = 0.02) and MS instability (MSI; FoxP3+; P = 0.02). In stage II MS-stable cancers, concomitant low densities of both FoxP3+ and CD3+ TILs identified patients with the highest progression risk in the trial [HR 7.24; 95% confidence interva...Continue Reading

References

Jul 23, 2003·The Journal of Experimental Medicine·Lucy S K WalkerAbul K Abbas
May 19, 2005·Cancer Research·Susan E ErdmanDavid B Schauer
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alberto MalesciArmando Santoro
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul SalamaBarry Iacopetta
Apr 23, 2009·Cancer Research·Ilona KryczekWeiping Zou
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Franck PagèsJérôme Galon
Nov 13, 2009·Cancer Immunology, Immunotherapy : CII·Hiroyuki SuzukiMitsuo Katano
Apr 28, 2010·Gastroenterology·Janos TerzićMichael Karin
Jun 7, 2011·Cancer Immunology, Immunotherapy : CII·Sylvain LadoireFrançois Ghiringhelli
Jul 7, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Eliane C M ZeestratenPeter J K Kuppen
Apr 13, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Luigi LaghiAlberto Malesci
Apr 19, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ronald J deLeeuwBrad H Nelson
Oct 30, 2012·Journal of the National Cancer Institute·Arnaud D RothEric Van Cutsem
Oct 15, 2013·The Journal of Pathology·Jérôme GalonFranck Pagès
Jan 1, 2011·Cancers·Francesca BergomasFederica Marchesi
Dec 3, 2014·Journal of the American College of Surgeons·Sandy H FangSteven D Wexner
Dec 3, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena M StoffelUNKNOWN European Society of Clinical Oncology
Mar 5, 2016·International Journal of Cancer. Journal International Du Cancer·Maria Rosaria GaldieroSébastien Jaillon
Mar 29, 2018·The New England Journal of Medicine·Axel GrotheyTimothy Iveson
Apr 6, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto SobreroUNKNOWN TOSCA Investigators

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Citations

Jul 16, 2019·International Journal of Cancer. Journal International Du Cancer·Chen ZhouJie Cheng
Dec 6, 2019·American Journal of Clinical Pathology·Sam SadighPriti Lal
May 27, 2020·British Journal of Cancer·Anita L RayKatherine T Morris
Jul 20, 2020·International Journal of Cancer. Journal International Du Cancer·Aysel AhadovaMatthias Kloor
Mar 4, 2020·The Journal of Clinical Investigation·Giorgia AlvisiEnrico Lugli
Dec 24, 2020·International Journal of Molecular Sciences·Luigi LaghiAlberto Malesci
Jun 3, 2021·International Journal of Molecular Sciences·Federica GaianiLuigi Laghi
Jan 11, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jeonghyun KangKang Young Lee

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