Abstract
Serum CA15-3 has been one of the most reliable tumor markers used in monitoring breast cancer patients; however, its sensitivity in detecting metastases is limited. To increase its sensitivity, the combined measurement of other tumor markers with CA15-3 was investigated. Serum CA15-3, carcinoembryonic antigen (CEA) and sialyl Lewis X (CSLEX) were simultaneously measured in a prospective series of 455 postoperative breast cancer patients with or without metastasis. The diagnostic parameters sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for detecting metastases were compared. The correlation of values between pairs of tumor markers was analyzed. The efficacy of combined measurement of two different tumor markers was also evaluated. The sensitivity for detecting metastases was 61.5, 56.9 and 52.3%; specificity was 97.2, 93.6 and 96.2%; PPV was 78.4, 59.7 and 69.4%; NPV was 93.8, 92.9 and 92.4%; and accuracy was 92.1, 88.8 and 89.9% for CA15-3, CEA and CSLEX, respectively. The values for CA15-3 were significantly correlated with those for CEA (P < 0.001) but not those for CSLEX. The combined measurement of CSLEX and CA15-3 increased the sensitivity by 17.0% but that of CEA a...Continue Reading
References
Oct 6, 1984·Lancet·T IguroM Kawahara
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A MartoniF Pannuti
Jul 1, 1995·British Journal of Cancer·J F RobertsonR W Blamey
Jun 1, 1997·Japanese Journal of Clinical Oncology·N MatsuuraH Takagi
Dec 6, 2000·British Journal of Cancer·N FutamuraH Hirose
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R C BastUNKNOWN American Society of Clinical Oncology Tumor Markers Expert Panel
Oct 27, 2001·Breast Cancer Research and Treatment·R D'AlessandroF Guadagni
Apr 16, 2002·British Journal of Cancer·F G EbelingD Seidel
Jan 15, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Junichi KurebayashiUNKNOWN Tumor Marker Study Group of the Japanese Breast Cancer Society, Japan
May 14, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F GuadagniM Roselli
Dec 18, 2004·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Junichi KurebayashiTetsuya Taguchi
Citations
Jun 16, 2012·Cancer Metastasis Reviews·Matthew J SchultzSusan L Bellis
Nov 16, 2012·Journal of Biosciences·Noé Velázquez-MárquezVerónica Vallejo-Ruiz
Sep 27, 2008·Glycobiology·Umi M Abd HamidPauline M Rudd
Apr 22, 2011·Glycobiology·Simon A FryAnthony J C Leathem
Oct 20, 2010·Japanese Journal of Clinical Oncology·Tomoyuki FujitaMinoru Fujimori
Jun 17, 2010·Breast Cancer Research : BCR·Aurélie CazetPhilippe Delannoy
Jan 4, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anders CarlssonCarl A K Borrebaeck
Jul 23, 2008·Proteomics·James N ArnoldPauline M Rudd
Oct 1, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Gordon GrevilleRadka Saldova
Jan 1, 2012·Metabolites·Tatiana PochechuevaViola Heinzelmann-Schwarz
May 6, 2019·Breast Cancer Research and Treatment·Evan N CohenJames M Reuben
Oct 30, 2016·Clinical Chemistry·J YamashitaH Ishihara
Oct 16, 2019·Electrophoresis·Worapot Suntornsuk, Leena Suntornsuk
Aug 20, 2011·Chemical Communications : Chem Comm·Chaofeng DaiBinghe Wang
Sep 25, 2010·Biochemical Society Transactions·Li LiuPauline M Rudd
Mar 17, 2010·Carbohydrate Research·Aurélie CazetPhilippe Delannoy