PMID: 9179463Mar 1, 1997Paper

Combined measurements of GAD65 and ICA512 antibodies in acute onset and slowly progressive IDDM

Diabetes Research and Clinical Practice
K YamadaK Nonaka

Abstract

Autoantibodies to 65 kD glutamic acid decarboxylase (GADAA) and ICA512 (ICA512AA) were measured by radioimmunoassays using as antigens in vitro transcribed and translated [35S]-methionine-labeled human GAD65 and ICA512 (IA-2). The prevalence of GADAA and ICA512AA in sera from 87 patients with IDDM was 39 and 23%, respectively. The frequency and titer of ICA512AA declined sharply within 5 years after the onset of IDDM. Among patients tested within 4 years after diagnosis, the prevalence of ICA512AA was significantly higher in acute onset IDDM than in slowly progressive IDDM (37 versus 6%, P < 0.025) irrespective of age, while there was no difference in GADAA frequency between acute onset and slowly progressive subtypes (51 versus 63%). A total of two patients out of 121 patients with NIDDM were positive for GADAA, and two other NIDDM patients, who were suffering from sarcoidosis, were positive for ICA512AA. Neither of the antibodies were positive in sera from four atypical NIDDM patients, aged < 20 years, who showed ketosis at onset and required insulin followed by excellent metabolic control with diet restriction alone. These observations suggest that ICA512AA are associated with rapid progression of beta cell damage in IDDM. I...Continue Reading

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Citations

Aug 29, 2000·Diabetes Research and Clinical Practice·S NakamotoT Saruta
May 30, 2001·Diabetes Research and Clinical Practice·R GoswamiN K Maclaren
Feb 27, 2003·Journal of Autoimmunity·Ryuji SuzukiShosaku Narumi
Oct 12, 2001·Biochemical and Biophysical Research Communications·S ShimizuT Onodera
Jan 6, 2009·Annals of the New York Academy of Sciences·Eiji KawasakiKatsumi Eguchi
Apr 30, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Tatsuhiko UrakamiHideo Mugishima
Apr 6, 2001·Diabetes Care·A ShimadaS Narumi
Dec 29, 2004·Diabetes Research and Clinical Practice·Tsuguhito OtaRika Usuda
May 22, 2002·Annals of the New York Academy of Sciences·Tetsuro KobayashiJunichi Yokoyama

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