Combined measurements of serum bile acid level and splenic volume may be useful to noninvasively assess portal venous pressure.

Journal of Gastroenterology
H HayashiHideo Baba

Abstract

We aimed to identify a noninvasive predictor of portal venous pressure (PVP). We directly measured the PVP in 40 consecutive patients who underwent direct percutaneous transhepatic portal vein puncture as part of the therapeutic management for liver diseases, and we evaluated the association of the PVP with noninvasive clinical parameters. The backgrounds of the liver were normal in 13 patients, chronic hepatitis in 17, and liver cirrhosis in ten. The mean PVP was 202 ± 114 mmH(2)O. In a multivariate linear regression analysis, the serum bile acid level and splenic volume showed independent positive correlations with the PVP (P < 0.001 and 0.002, respectively). The formula for estimating PVP was identified as follows: PVP (mmH(2)O) = serum bile acid (μmol/L) × 2.593 + splenic volume (cm(3)) × 0.416 + 65.929 (R(2) = 0.698). In a receiver operating characteristic (ROC) analysis, the AUC values of serum bile acid and splenic volume at a PVP of 200 mmH(2)O were 0.909 and 0.758, respectively. However, the AUC values of serum bile acid and splenic volume at a PVP of 250 mmH(2)O were 0.792 and 0.926, respectively, suggesting that the serum bile acid level and splenic volume are sensitive predictors of early and advanced portal hyperte...Continue Reading

References

Aug 1, 1974·European Journal of Clinical Investigation·R HerzR Preisig
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Feb 14, 2007·Journal of Gastroenterology and Hepatology·Kaori KadouchiTetsuo Arakawa
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Sanjay Kumar Sharma, Rakesh Aggarwal
Apr 17, 2008·The British Journal of Surgery·H HayashiH Baba
Oct 3, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Makoto Segawa, Isao Sakaida
Jan 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominique ThabutDidier Lebrec

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Citations

Jun 30, 2014·The Journal of Surgical Research·Atsushi NanashimaTakeshi Nagayasu
Feb 11, 2016·Journal of Digestive Diseases·Qian Wen ZhangWei Fen Xie
Aug 18, 2018·Contrast Media & Molecular Imaging·Lukas HaiderAhmed Ba-Ssalamah

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