Combined millimeter wave and cyclophosphamide therapy of an experimental murine melanoma

Bioelectromagnetics
M K LoganiM C Ziskin

Abstract

The objective of the present studies was to investigate whether millimeter wave (MMW) therapy can increase the efficacy of cyclophosphamide (CPA), a commonly used anti-cancer drug. The effect of combined MMW-CPA treatment on melanoma growth was compared to CPA treatment alone in a murine model. MMWs were produced with a Russian made YAV-1 generator. The device produced 42.2 +/- 0.2 GHz modulated wave radiation through a 10 x 20 mm rectangular output horn. The animals, SKH-1 hairless female mice, were irradiated on the nasal area. Peak SAR and incident power density were measured as 730 +/- 100 W/kg and 36.5 +/- 5 mW/cm2, respectively. The maximum skin surface temperature elevation measured at the end of 30 min irradiation was 1.5 degrees C. B16F10 melanoma cells (0.2 x 10(6)) were implanted subcutaneously into the left flank of mice on day 1 of the experiment. On days 4-8, CPA was administered intraperitoneally (30 mg/kg/day). MMW irradiation was applied concurrently with, prior to or following CPA administration. A significant reduction (P < .05) in tumor growth was observed with CPA treatment, but MMW irradiation did not provide additional therapeutic benefit as compared to CPA alone. Similar results were obtained when MMW ir...Continue Reading

References

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Oct 24, 2002·Bioelectromagnetics·Mahendra K LoganiMarvin C Ziskin
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Jun 24, 2003·Bioelectromagnetics·Vera MakarMarvin Ziskin
Nov 7, 2003·Bioelectromagnetics·S I Alekseev, M C Ziskin

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Citations

Jun 19, 2010·QJM : Monthly Journal of the Association of Physicians·D T Pooley
Jan 27, 2006·Bioelectromagnetics·Mahendra K LoganiMarvin C Ziskin
Jun 9, 2011·Immunopharmacology and Immunotoxicology·Mahendra K LoganiMarvin C Ziskin
Dec 26, 2017·Frontiers in Public Health·Zenon SienkiewiczMyron Maslanyj

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