Abstract
One hundred ten patients with epidermoid carcinoma of the esophagus were treated at the Memorial Sloan-Kettering Cancer Center (MSKCC) with combined modality techniques involving preoperative irradiation (RT) and surgery, and with preoperative chemotherapy (CT), surgery, and irradiation. For the 76 patients receiving preoperative RT during the period 1965-1976, the overall resectability rate was 54% with an operative mortality of 12%; long-term survivors (greater than 3 years) were few (7%). For 34 patients receiving preoperative CT with cisplatin and bleomycin, major objective tumor regression (greater than 50%) was seen by day 18 in 20%, with an additional 44% having smaller but definite improvement in the barium esophagram and in swallowing function. Of those receiving preoperative CT, 76% had resectable lesions, with an operative mortality of 11%. The median follow-up for this group is 24 months; of the 30 patients followed for at least 12 months, 20% are alive without evidence of disease. Although the resection rate following preoperative chemotherapy seems to be higher, thus allowing better palliation, neither preoperative radiation nor chemotherapy with cisplatin and bleomycin have had a major impact on long-term survival.
References
Jul 1, 1976·Cancer·R D MarksK M Wallace
Jan 1, 1975·Journal of Surgical Oncology·V B RamboE F Parker
Apr 1, 1972·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G BonadonnaF Fossati-Bellani
May 1, 1970·Annals of Surgery·E F ParkerJ M Ravenel
Jan 14, 1974·JAMA : the Journal of the American Medical Association·K Nakayama, Y Kinoshita
Feb 1, 1969·American Journal of Surgery·J M GuernseyH A Oberhelman
Oct 1, 1971·The British Journal of Surgery·J G Pearson
Jan 1, 1970·Chest·I AkakuraH Yamashita
Jun 13, 1970·British Medical Journal
Jun 1, 1967·The Surgical Clinics of North America·D P Boyd, M C Kim
Citations
Jun 1, 1992·Journal of Surgical Oncology·J A Roth
Mar 1, 1995·World Journal of Surgery·J A Roth
May 1, 1994·World Journal of Surgery·T NishihiraS Mori
Aug 1, 1987·World Journal of Surgery·M GignouxN Duez
Jan 1, 1982·The Japanese Journal of Surgery·Y OkudairaH Matsuura
Jan 1, 1992·Photochemistry and Photobiology·D T RibeiroC F Menck
Mar 1, 1986·Acta Radiologica. Oncology·J G van AndelM Eeftinck Schattenkerk
Jan 1, 1994·Acta Oncologica·J FagerbergR Lewensohn
Jan 1, 1990·Acta Oncologica·P Kellokumpu-LehtinenV Nikkanen
Jan 1, 1990·Acta Oncologica·M Albertsson, G M Hambraeus
Apr 1, 1988·The Annals of Thoracic Surgery·C F Mountain
Nov 1, 1982·The Annals of Thoracic Surgery·M S BainsN Martini
Apr 1, 1991·International Journal of Radiation Oncology, Biology, Physics·Y HishikawaT Miura
Nov 1, 1988·Seminars in Oncology Nursing·B R Medvec
Oct 1, 1984·American Journal of Surgery·C F Collin, R H Spiro
Oct 1, 1983·The American Journal of Medicine·D KelsenM Bains
Aug 1, 1988·Current Problems in Surgery·T R DeMeester, A P Barlow
Jul 1, 1988·Current Problems in Surgery·T R DeMeester, A P Barlow
Sep 1, 1988·Current Problems in Cancer·T R DeMeester, A P Barlow
Jun 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R HatlevollB Rosengren
Jan 1, 1988·The Korean Journal of Internal Medicine·C M KimS Y Yoo
Feb 1, 1993·Cancer·K KondoT Katsuki
Jan 15, 1992·Cancer·S G UrbaA Forastiere
Jan 15, 1988·Cancer·K S SridharH Manten
Sep 1, 1988·Cancer·G M HambraeusT Landberg
Jun 1, 1985·Cancer·K MoritaH Kanazawa
Oct 1, 1985·Cancer·S H AdvaniP B Desai
Dec 1, 1984·Cancer·C J CoonleyD P Kelsen
Sep 1, 1984·Cancer·D J AdelsteinB Beavers
Mar 15, 1982·Cancer·D P KelsenN Martini