PMID: 6164465Feb 15, 1981Paper

Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group

Cancer
K KristiansenK Elgen

Abstract

In a controlled, prospective, randomized investigation, started in 1974, 118 patients with supratentorial astrocytoma Grade III--IV were divided into three groups. Groups 1 and 2 received 45 Gy postoperatively to the whole supratentorial brain. Bleomycin in 15-mg doses and a total dose of 180 mg or placebo was given intravenously three times a week, one hour prior to radiotherapy, during weeks 1, 2, 4 and 5. Group 3 received conventional care but no radiotherapy or chemotherapy. Median survival rates of patients were 10.8 months in Groups 1 and 2, and 5.2 months in Groups 3, a statistically significant difference. With regard to performance, the patients in Group 3 deteriorated faster than patients in Groups 1 and 2. Bleomycin had no positive or negative influence on survival.

References

Jun 1, 1974·The British Journal of Radiology·N M BleehenP R Twentyman

❮ Previous
Next ❯

Citations

Jan 4, 1998·Seminars in Surgical Oncology·D A Larson, W M Wara
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·C ThilmannJ Debus
Jan 1, 1993·Journal of Neuro-oncology·F B CvitkovicJ P Constans
Jan 1, 1994·Journal of Neuro-oncology·H A Fine
Jan 1, 1995·Journal of Neuro-oncology·A T BergenheimR Henriksson
Jan 1, 1984·Neurosurgical Review·Y UshioN Arita
Sep 30, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Maaike J VosJan J Heimans
Dec 13, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Andor W J M GlaudemansRiemer H J A Slart
Aug 16, 2012·International Journal of Clinical Oncology·Mariangela MassaccesiAlessio G Morganti
Oct 13, 2006·Current Treatment Options in Oncology·Lyndon Kim, Michael Glantz
Dec 21, 2000·Current Oncology Reports·M E Linskey
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·B J SlotmanA B Karim
Oct 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E SalminenS Huhtala
Sep 1, 1992·Seizure : the Journal of the British Epilepsy Association·D Chadwick
Apr 26, 2005·Cancer Treatment Reviews·Sara LonardiAlba A Brandes
Apr 9, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tom B JohannesenHenry Hirschberg
Sep 21, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Normand LaperriereUNKNOWN Cancer Care Ontario Practice Guidelines Initiative Neuro-Oncology Disease Site Group
Jun 19, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J J McAleeseMichael Brada
Jul 30, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claire PhillipsGeorge Quong
Jun 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C Fallai, P Olmi
Jul 1, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B JeremicJ Aleksandrovic
Mar 4, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M C HulshofD González González
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·L PaszatE Holowaty
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·M P SunyachD Frappaz
Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·T PicklesJ Bowen
Apr 16, 1998·International Journal of Radiation Oncology, Biology, Physics·K NakagawaA Akanuma
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·N J LaperriereM Bernstein
Feb 25, 1999·International Journal of Radiation Oncology, Biology, Physics·M BradaS Ashley
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S GundersenK Watne
Mar 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A A BrandesS Monfardini
Sep 10, 2002·The Lancet Oncology·Tejpal Gupta, Rajiv Sarin
Apr 13, 2007·The New England Journal of Medicine·Florence Keime-GuibertUNKNOWN Association of French-Speaking Neuro-Oncologists
Apr 2, 2004·American Journal of Clinical Oncology·Branislav JeremicNebojsa Nikolic
Apr 18, 2007·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael R LevittVikram C Prabhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.