PMID: 16639877Apr 28, 2006Paper

Combined n-benzoyl-d-phenylalanine and metformin treatment reverses changes in the fatty acid composition of streptozotocin diabetic rats

Journal of Basic and Clinical Physiology and Pharmacology
Natarajan Ashok Kumar, Leelavinothan Pari

Abstract

The present investigation was carried out to evaluate the effect of N-benzoyl-D-phenylalanine (NBDP) and metformin on blood glucose, plasma insulin, and on the fatty acid composition of total lipids in the livers and kidneys of control and experimental diabetic rats. When compared with nondiabetic control rats, neonatal streptozotocin (nSTZ) diabetic rats showed a significant increase in blood glucose and decreased plasma insulin. Analysis of fatty acids revealed a significant increase in the concentration of palmitic, stearic, and oleic acids in liver and kidney, whereas linolenic and arachidonic acids were significantly decreased. In diabetic rats, the oral administration of combined NBDP/metformin for 6 wk decreased the high concentrations of palmitic, stearic, and oleic acids and elevated the low levels of linolenic and arachidonic acids. The results suggest that the NBDP/metformin combination exhibits both antidiabetic and antihyperlipidemic effects in nSTZ diabetic rats and prevents the fatty acid changes produced during diabetes.

References

Apr 1, 1987·Diabetes/metabolism Reviews·K PyöräläM Uusitupa
Dec 10, 1999·Diabetes Research and Clinical Practice·N E Cameron, M A Cotter
Jul 13, 2000·The British Journal of Nutrition·B Vessby
Nov 26, 2003·Japanese Journal of Ophthalmology·Destan Nil KulacogluOrhan Baykal
Nov 27, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Natarajan Ashokkumar, Leelavinothan Pari

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Citations

Sep 13, 2011·Chemico-biological Interactions·Natalia C HabibSara S Sánchez
Dec 11, 2008·Basic & Clinical Pharmacology & Toxicology·Kunga Mohan RamkumarPalanisamy Rajaguru

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