Combined optical and single photon emission imaging: preliminary results

Physics in Medicine and Biology
Federico BoschiAndrea Sbarbati

Abstract

In vivo optical imaging instruments are generally devoted to the acquisition of light coming from fluorescence or bioluminescence processes. Recently, an instrument was conceived with radioisotopic detection capabilities (Kodak in Vivo Multispectral System F) based on the conversion of x-rays from the phosphorus screen. The goal of this work is to demonstrate that an optical imager (IVIS 200, Xenogen Corp., Alameda, USA), designed for in vivo acquisitions of small animals in bioluminescent and fluorescent modalities, can even be employed to detect signals due to radioactive tracers. Our system is based on scintillator crystals for the conversion of high-energy rays and a collimator. No hardware modifications are required. Crystals alone permit the acquisition of photons coming from an in vivo 20 g nude mouse injected with a solution of methyl diphosphonate technetium 99 metastable (Tc99m-MDP). With scintillator crystals and collimators, a set of measurements aimed to fully characterize the system resolution was carried out. More precisely, system point spread function and modulation transfer function were measured at different source depths. Results show that system resolution is always better than 1.3 mm when the source depth ...Continue Reading

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Citations

Nov 25, 2011·Journal of Biomedical Optics·Antonello E SpinelliFederico Boschi
Jan 4, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Antonello E Spinelli, Federico Boschi
Apr 28, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Antonello E Spinelli, Federico Boschi
Oct 27, 2016·Medical Physics·Martin T KingLei Xing
Apr 14, 2018·Journal of Biomedical Optics·Antonello E SpinelliFederico Boschi
May 18, 2018·Journal of Biophotonics·Federico BoschiAntonello E Spinelli
Aug 19, 2017·Journal of Biomedical Optics·Nicole L AckermanAntonello E Spinelli
Dec 22, 2009·Physics in Medicine and Biology·Antonello E SpinelliFederico Boschi
Mar 5, 2019·Australasian Physical & Engineering Sciences in Medicine·Changran GengFada Guan
Jan 13, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Flora L Thorp-Greenwood, Michael P Coogan
Oct 22, 2017·Journal of Biophotonics·Federico BoschiAntonello E Spinelli
Jun 27, 2015·Biomedical Optics Express·Antonello E SpinelliFederico Boschi
Jan 29, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Masako ShimamotoAkihiro Kojima
Apr 25, 2018·Biomedical Engineering Online·Xuanxuan ZhangXu Cao
Jul 25, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Martin T KingLei Xing
Nov 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Travis M ShafferJan Grimm
Nov 15, 2017·ACS Applied Materials & Interfaces·Julian R SilvermanGeorge John

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