Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression.

IEEE Transactions on Medical Imaging
Qianqian FangDavid A Boas

Abstract

In this paper, we report new progress in developing the instrument and software platform of a combined X-ray mammography/diffuse optical breast imaging system. Particularly, we focus on system validation using a series of balloon phantom experiments and the optical image analysis of 49 healthy patients. Using the finite-element method for forward modeling and a regularized Gauss-Newton method for parameter reconstruction, we recovered the inclusions inside the phantom and the hemoglobin images of the human breasts. An enhanced coupling coefficient estimation scheme was also incorporated to improve the accuracy and robustness of the reconstructions. The recovered average total hemoglobin concentration (HbT) and oxygen saturation (SO2) from 68 breast measurements are 16.2 microm and 71%, respectively, where the HbT presents a linear trend with breast density. The low HbT value compared to literature is likely due to the associated mammographic compression. From the spatially co-registered optical/X-ray images, we can identify the chest-wall muscle, fatty tissue, and fibroglandular regions with an average HbT of 20.1+/-6.1 microm for fibroglandular tissue, 15.4+/-5.0 microm for adipose, and 22.2+/-7.3 microm for muscle tissue. The...Continue Reading

References

Oct 1, 1994·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·R C HaskellB J Tromberg
Feb 1, 1993·Journal of Biomechanical Engineering·C T LiauhR B Roemer
May 1, 1997·Physics in Medicine and Biology·J C HebdenD T Delpy
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S R Arridge, M Schweiger
Mar 16, 2001·Academic Radiology·A E CerussiB J Tromberg
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·N ShahB Tromberg
Sep 12, 2002·Physics in Medicine and Biology·T DurduranA G Yodh
Oct 9, 2002·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Seungseok OhKevin J Webb
Apr 16, 2004·IEEE Transactions on Medical Imaging·Qianqian FangKeith D Paulsen
Mar 19, 2005·Physics in Medicine and Biology·A P GibsonS R Arridge
Apr 9, 2005·Applied Optics·Tanja TarvainenJari P Kaipio
Apr 21, 2005·Applied Optics·Antonio PifferiHermann Stamm
May 25, 2005·Journal of Biomedical Optics·Quan ZhangDavid A Boas
Aug 30, 2005·Journal of Biomechanics·Amy E KerdokRobert D Howe
Sep 13, 2006·Journal of Biomedical Optics·Juliette SelbDavid A Boas
Dec 16, 2006·Ultrasound in Medicine & Biology·Gearóid P BerryCecil G Armstrong
Apr 21, 2007·Applied Optics·Martin SchweigerSimon R Arridge
Jan 1, 1995·IEEE Transactions on Medical Imaging·K D PaulsenJ R Sullivan

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Citations

Sep 25, 2009·Targeted Oncology·Louise C EnfieldMichael Douek
Aug 3, 2010·Nature Methods·Vasilis Ntziachristos
Jul 8, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Adam Gibson, Hamid Dehghani
Aug 3, 2011·Journal of Biomedical Optics·Wenfeng XiaSrirang Manohar
Aug 3, 2011·Journal of Biomedical Optics·Molly L FlexmanAndreas H Hielscher
Aug 3, 2011·Journal of Biomedical Optics·Yan XuQuing Zhu
Dec 12, 2012·Journal of Biomedical Optics·Paul C PearlmanJosien P W Pluim
Jul 24, 2010·AJR. American Journal of Roentgenology·Brian W PogueKeith D Paulsen
Mar 3, 2011·The Review of Scientific Instruments·Dirk GrosenickRainer Macdonald
Oct 5, 2013·Medical Physics·Paul M MeaneyKeith D Paulsen
Nov 11, 2010·Radiology·Qianqian FangDavid A Boas
Jan 5, 2011·Journal of Biomedical Optics·Christian D KloseAndreas H Hielscher
Jan 21, 2014·Academic Radiology·David R BuschArjun G Yodh
Dec 24, 2011·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Rabah Al abdiRandall L Barbour
Nov 8, 2012·Journal of Biophotonics·Alexander Poellinger
Mar 5, 2010·IEEE Transactions on Medical Imaging·Enzhuo Michelle Quan, David S Lalush
Jan 1, 2010·IEEE Journal of Quantum Electronics·Jing LiuBruce J Tromberg
Dec 18, 2012·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Regine Choe, Turgut Durduran
Sep 4, 2010·IEEE Transactions on Medical Imaging·Colin M CarpenterKeith D Paulsen
Jan 25, 2011·Biomedical Optics Express·Qianqian FangDavid A Boas
Jul 5, 2011·Computers in Biology and Medicine·Amir TahmasbiShahriar B Shokouhi
Mar 5, 2016·The Review of Scientific Instruments·Nishanth KrishnamurthySergio Fantini
Dec 17, 2016·Journal of X-ray Science and Technology·Reheman BaikejiangChangqing Li
Apr 6, 2017·AJR. American Journal of Roentgenology·Giovanni Di LeoFrancesco Sardanelli
Oct 20, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sihua NiuYu Xiao
Jan 28, 2016·Journal of Biomedical Optics·Bernhard B ZimmermannStefan A Carp
Jul 1, 2010·Reports on Progress in Physics·T DurduranA G Yodh

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