Combined overdose with verapamil and atenolol: treatment with high doses of adrenergic agonists

Acta Anaesthesiologica Scandinavica
S KalmanB Lisander

Abstract

A 55-year-old man was admitted following an overdose of sustained-release verapamil (calcium channel blocker) and ordinary-release atenolol (beta-1 blocker). At admission, there was extreme bradycardia (20-25 beats min-1) and hypotension (systolic arterial pressure 40-50 mm Hg). To counteract the cardiovascular depression, prenalterol, dopamine, dobutamine, isoprenaline, adrenaline and noradrenaline were used. A satisfactory state was obtained with adrenaline, noradrenaline and dopamine infused at high rates. Cardiac output was then more than 101 min-1, with a very low total peripheral resistance. The infusion of the adrenergic agonists could be interrupted on day 3. Prolonged ventilator treatment was necessary but the patient recovered without sequelae. Treatment options for similar cases are outlined.

References

Nov 1, 1992·The Annals of Pharmacotherapy·S M WatlingR A Stiller
Jan 1, 1990·Life Sciences·B G Benfey
Apr 15, 1990·Biochemical Pharmacology·J Ferrante, D J Triggle
Jul 1, 1985·The American Journal of Emergency Medicine·M HenryP Viccellio
Nov 1, 1986·Annals of Emergency Medicine·T AnthonyH Prasad
Mar 1, 1983·Clinics in Endocrinology and Metabolism·B B Hoffman
Jun 1, 1983·Clinical Pharmacology and Therapeutics·U DahlströmL Jorfeldt
May 1, 1994·The American Journal of Emergency Medicine·J N Love
Oct 1, 1993·The American Journal of Medicine·C A HoferM F Tenholder
Jan 1, 1993·Journal of Toxicology. Clinical Toxicology·H TakahashiH Naito
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·D M ReithG P Sayer
Jun 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S GurtuS Shukla
Jul 1, 1996·Journal of Clinical Epidemiology·B B GerstmanR Platt

❮ Previous
Next ❯

Citations

May 19, 2005·Toxicological Reviews·Christopher R DeWitt, Javier C Waksman
Sep 16, 2014·The Journal of Emergency Medicine·Ronald KoschnyChristoph Eisenbach
Oct 7, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·M St-OngeR Blais
Jun 16, 2004·Acta Anaesthesiologica Scandinavica·C SandroniM Antonelli
Jan 13, 2000·American Journal of Clinical Pathology·Z TangG J Kost
Oct 4, 2005·Emergency Medicine Clinics of North America·Christopher P Holstege, Stephen Dobmeier
Dec 8, 2007·Journal of Intensive Care Medicine·Jacek KolczEdward Malec
Oct 18, 2012·Physiological Reviews·Kenneth B Gagnon, Eric Delpire
Apr 21, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Joe-Anthony RotellaAnselm Wong
Jan 31, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kent R OlsonUNKNOWN American Association of Poison Control Centers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Related Papers

The American Journal of Emergency Medicine
L ProanoR Y Wang
European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
Vladimir TukaEva Kotrlikova
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
W KernsR Raymond
© 2022 Meta ULC. All rights reserved