Combined papillary and mucoepidermoid carcinoma of the thyroid gland: a possible collision tumor diagnosed on fine-needle cytology. Report of a case with immunocytochemical and molecular correlations

Endocrine Pathology
Franco FulcinitiGennaro Chiappetta

Abstract

Fine-needle cytology (FNC) is frequently used to diagnose thyroid nodules discovered by palpation or imaging studies. Molecular tests on FNC material may increase its diagnostic accuracy. We report a case of a classic papillary thyroid carcinoma combined with a mucoepidermoid carcinoma correctly identified on FNC. The papillary component had a classic immunophenotype (CK19+, TTF1+), while the mucoepidermoid one was only focally CK19+. Point mutations (BRAF and RAS) and rearrangements (RET/PTC) of the papillary component have been also investigated on FNC samples, with resulting concurrent rearrangements of RET/PTC1 and RET/PTC3, but no point mutations. The histogenesis of combined papillary and mucoepidermoid carcinoma of the thyroid still remains partly unsettled, and further genomic studies are needed to shed some more light on this peculiar neoplasm.

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Citations

Apr 24, 2016·American Journal of Otolaryngology·Andrés Coca-PelazAlfio Ferlito
Jul 8, 2020·Endocrine Pathology·José Manuel Cameselle-TeijeiroManuel Sobrinho-Simões
Jun 21, 2020·Head and Neck Pathology·Meagan ChambersDarcy A Kerr
Jul 21, 2021·Archives of Endocrinology and Metabolism·Marcos Tadashi Kakitani ToyoshimaAna Oliveira Hoff

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