Combined Plasma and Tissue Proteomic Study of Atherogenic Model Mouse: Approach To Elucidate Molecular Determinants in Atherosclerosis Development

Journal of Proteome Research
Hiroko HanzawaYuji Kuge

Abstract

Atherogenic cardiovascular diseases are the major cause of mortality. Prevention and prediction of incidents is important; however, biomarkers that directly reflect the disease progression remain poorly investigated. To elucidate molecular determinants of atherogenesis, proteomic approaches are advantageous by using model animals for comparing changes occurring systematically (bloodstream) and locally (lesion) in accordance with the disease progression stages. We conducted differential mass spectrometric analysis between apolipoprotein E deficient (apoED) and wild-type (wt) mice using the plasma and arterial tissue of both types of mice obtained at four pathognomonic time points of the disease. A total of 100 proteins in the plasma and 390 in the arterial tissues were continuously detected throughout the four time points; 29 were identified in common. Of those, 13 proteins in the plasma and 36 in the arterial tissues showed significant difference in abundance between the apoED and wt mice at certain time points. Importantly, we found that quantitative variation patterns regarding the pathognomonic time points did not always correspond between the plasma and arterial tissues, resulting in gaining insight into atherosclerotic pla...Continue Reading

References

Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y NakashimaR Ross
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R L ReddickN Maeda
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jul 14, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·K YasojimaP L McGeer
Feb 28, 2002·Journal of Atherosclerosis and Thrombosis·Y MatsushimaM Tachibana
May 1, 2002·Electrophoresis·Jean-Daniel TissotMichel A Duchosal
Aug 24, 2002·Circulation Research·Göran K HanssonZhong-Qun Yan
Mar 14, 2003·Nature·Sam Hanash
Apr 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Karen S Meir, Eran Leitersdorf
Aug 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·David SeoPascal J Goldschmidt-Clermont
Sep 24, 2004·Molecular & Cellular Proteomics : MCP·Philip L RossDarryl J Pappin
Dec 22, 2004·The Journal of Physiology·Leigh Anderson
Jan 19, 2006·Physiological Genomics·Raymond TabibiazarThomas Quertermous
Nov 4, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Wolfgang Koenig, Natalie Khuseyinova
Oct 24, 2007·Molecular & Cellular Proteomics : MCP·Lukas U ZimmerliAnna F Dominiczak
Sep 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yan ZhaoNagara Tamaki
Jun 5, 2010·Advances in Clinical Chemistry·Xinkang Wang, Thomas M Connolly
Jun 17, 2010·Molecular & Cellular Proteomics : MCP·Athanasios DidangelosManuel Mayr
Dec 16, 2010·Journal of Thrombosis and Haemostasis : JTH·W S SpeidlJ Wojta
Mar 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Yasumi UchidaToshihiro Morita
Apr 27, 2011·Expert Review of Cardiovascular Therapy·Giovanni CimminoPaolo Golino
Oct 23, 2012·Alcoholism, Clinical and Experimental Research·Mako YamadaFumio Nomura
Jul 22, 2014·Biochimica Et Biophysica Acta·Junyan Xu, Guo-Ping Shi

❮ Previous
Next ❯

Citations

May 31, 2016·Biochimica Et Biophysica Acta·Viorel-Iulian SuicaFelicia Antohe
Dec 17, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yoichi ShimizuYuji Kuge
Jul 12, 2017·Expert Review of Proteomics·Laura Mourino-AlvarezMaria G Barderas
Jun 20, 2018·Circulation·David M HerringtonJennifer E Van Eyk
Dec 21, 2016·Nuclear Medicine and Molecular Imaging·Yoichi Shimizu, Yuji Kuge
Sep 5, 2018·Chinese Journal of Integrative Medicine·Lan MaWei Mao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.