Combined predictive value of the expanded donor criteria for long-term graft survival of kidneys from donors after cardiac death: A single-center experience over three decades

International Journal of Urology : Official Journal of the Japanese Urological Association
Mamoru KusakaKiyotaka Hoshinaga

Abstract

Kidneys procured from the deceased hold great potential for expanding the donor pool. The aims of the present study were to investigate the post-transplant outcomes of renal allografts recovered from donors after cardiac death, to identify risk factors affecting the renal prognosis and to compare the long-term survival from donors after cardiac death according to the number of risk factors shown by expanded criteria donors. A total of 443 grafts recovered using an in situ regional cooling technique from 1983 to 2011 were assessed. To assess the combined predictive value of the significant expanded criteria donor risk criteria, the patients were divided into three groups: those with no expanded criteria donor risk factors (no risk), one expanded criteria donor risk factor (single-risk) and two or more expanded criteria donor risk factors (multiple-risk). Among the donor factors, age ≥50 years, hypertension, maximum serum creatinine level ≥1.5 mg/dL and a warm ischemia time ≥30 min were identified as independent predictors of long-term graft failure on multivariate analysis. Regarding the expanded criteria donors criteria for marginal donors, cerebrovascular disease, hypertension and maximum serum creatinine level ≥1.5 mg/dL were...Continue Reading

References

Jul 1, 1995·Lancet·R Matesanz, B Miranda
Apr 29, 1995·Lancet·R M WijnenG Kootstra
Jul 21, 2000·Annals of Surgery·J PratschkeN L Tilney
Oct 31, 2001·Transplantation·S G TulliusP Neuhaus
May 23, 2002·Transplantation·Igor A LaskowskiNicholas L Tilney
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert A MetzgerRobert M Merion
Jan 14, 2004·Kidney International·Abdulla K SalahudeenWarren May
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S GagandeepR Selby
Jan 16, 2007·Transplantation·Mamoru KusakaKiyotaka Hoshinaga
Jun 15, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C FondevilaJ C García-Valdecasas
Jan 2, 2009·The New England Journal of Medicine·Cyril MoersRutger J Ploeg
Apr 3, 2009·The New England Journal of Medicine·Christopher RayDavid Talbot
Jan 1, 1996·International Journal of Urology : Official Journal of the Japanese Urological Association·K HoshinagaY Naide
May 17, 2014·Journal of the American Society of Nephrology : JASN·Ajay K IsraniBertram L Kasiske

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Nov 6, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey S Isenberg, David D Roberts
Jun 23, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Paloma Barreda MonteolivaEmilio Rodrigo Calabria

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